HDAC6-IN-5
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
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- CAS No.: 2413603-15-1
- Formule: C20H14BrN3O2
- Masse moléculaire:408.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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AChE 0.72 μM (IC50) |
HDAC6 0.026 ± 0. μM (IC50) |
HDAC1 0.09 ± 0.0 μM (IC50) |
HDAC 0.16 ± 0.0 μM (IC50) |
HDAC3 0.33 ± 0. μM (IC50) |
HDAC2 0.48 ± 0.0 μM (IC50) |
HDAC9 5.51 ± 0.0 μM (IC50) |
HDAC5 7.19 ± 0.4 μM (IC50) |
HDAC4 7.85 ± 0.6 μM (IC50) |
HDAC7 9.13 ± 0.3 μM (IC50) |
HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413603-15-1
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Masse moléculaire 408.25
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Formule C20H14BrN3O2
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SMILES
O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-5 Related Classifications
HY-146678 Related Classifications
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