1. Cell Cycle/DNA Damage
    Epigenetics
    Neuronal Signaling
  2. HDAC
    Amyloid-β
    AChE
  3. HDAC6-IN-5

HDAC6-IN-5 

Cat. No.: HY-146678
Handling Instructions

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against 1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.

For research use only. We do not sell to patients.

HDAC6-IN-5 Chemical Structure

HDAC6-IN-5 Chemical Structure

CAS No. : 2413603-15-1

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Description

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against 1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].

IC50 & Target

HDAC6

0.026 ± 0. μM (IC50)

HDAC1

0.09 ± 0.0 μM (IC50)

HDAC

0.16 ± 0.0 μM (IC50)

HDAC3

0.33 ± 0. μM (IC50)

HDAC2

0.48 ± 0.0 μM (IC50)

HDAC9

5.51 ± 0.0 μM (IC50)

HDAC5

7.19 ± 0.4 μM (IC50)

HDAC4

7.85 ± 0.6 μM (IC50)

HDAC7

9.13 ± 0.3 μM (IC50)

In Vitro

HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

408.25

Formula

C20H14BrN3O2

CAS No.
SMILES

O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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HDAC6-IN-5
Cat. No.:
HY-146678
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