2413603-15-1

HDAC6-IN-5 Chemical Structure
2413603-15-1

Chemical Structure

HDAC6-IN-5

  • CAS No.: 2413603-15-1
  • Formula:C20H14BrN3O2
  • Molecular Weight:408.25

IUPAC Name: 4-((2-bromoacridin-9-yl)amino)-N-hydroxybenzamide

InChIKey: PESSDQDERPAVNH-UHFFFAOYSA-N

SMILES: O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO

Biological Activity: HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].

Cat. No. Product Name Purity Description Pricing
HY-146678 		HDAC6-IN-5 HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
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