1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. UF010

UF010 

Cat. No.: HY-18976 Purity: 99.36%
Handling Instructions

UF010 is a potent and selective HDAC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.

For research use only. We do not sell to patients.

UF010 Chemical Structure

UF010 Chemical Structure

CAS No. : 537672-41-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

UF010 is a potent and selective HDAC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8) Target: HDAC in vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.

IC50 & Target[1]

HDAC3

0.06 μM (IC50)

HDAC2

0.1 μM (IC50)

HDAC1

0.5 μM (IC50)

HDAC8

1.5 μM (IC50)

HDAC6

9.1 μM (IC50)

HDAC10

15.3 μM (IC50)

HDAC11

44.5 μM (IC50)

Molecular Weight

271.15

Formula

C₁₁H₁₅BrN₂O

CAS No.

537672-41-6

SMILES

O=C(NNCCCC)C1=CC=C(Br)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (368.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6880 mL 18.4400 mL 36.8800 mL
5 mM 0.7376 mL 3.6880 mL 7.3760 mL
10 mM 0.3688 mL 1.8440 mL 3.6880 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

UF010UF 010UF-010HDACHistone deacetylasesInhibitorinhibitorinhibit

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UF010
Cat. No.:
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