HDAC8-IN-4
HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC50s of 0.15 and 12 μM.
For research use only. We do not sell to patients.
- CAS No.: 1600528-05-9
- Formula: C17H14N2O2S2
- Molecular Weight:342.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC8 0.15 μM (IC50) |
HDAC3 12 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | GI50 |
2 μM
Compound: 41
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Growth inhibition of human Jurkat cells
Growth inhibition of human Jurkat cells
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[PMID: 37429084] |
HDAC8-IN-4 (Compound 9) (1 to 100 μM, 5-6 days) inhibits HDAC8 protein level in HeLa cells[1].
HDAC8-IN-4 (0-50 μM approximately, 72 h) inhibits T-cell lymphoma cells (Jurkat, HH, MT4, HUT78 cells) growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat, HH, MT4, HUT78 cells
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Concentration:0-50 μM approximately
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Incubation Time:72 h
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Result:Inhibited cell growth with IC50s of 2, 7.4, 5.8, 27 μM).
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Cell Line:HeLa cells
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Concentration:0-40 μM
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Incubation Time:4 h
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Result:Selectively inhibited HDAC8 over other HDACs in cells.
Chemical Information
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CAS No. 1600528-05-9
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Molecular Weight 342.44
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Formula C17H14N2O2S2
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SMILES
O=C(C1=CC=CC(C2=CSC(CSC3=CC=CC=C3)=N2)=C1)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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