HDAC-IN-27
Based on 1 Customer Validation
HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.12%
- No. CAS: 2763368-89-2
- Fòrmula: C20H22N4O2
- Peso molecular:350.41
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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HDAC1 3.01 nM (IC50) |
HDAC2 18.54 nM (IC50) |
HDAC3 0.435 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | GI50 |
69.6 nM
Compound: 9; 11h
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Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| HL-60 | IC50 |
26.21 nM
Compound: 11h
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Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| Kasumi 1 | GI50 |
17.49 nM
Compound: 9; 11h
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Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| MOLM-13 | IC50 |
40.4 nM
Compound: 11h
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Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| MV4-11 | GI50 |
37.3 nM
Compound: 9; 11h
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Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| MV4-11 | IC50 |
19.17 nM
Compound: 11h
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Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
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[PMID: 34942071] |
| MV4-11 | IC50 |
19.2 nM
Compound: 9; 11h
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Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| NB-4 | GI50 |
31.87 nM
Compound: 9; 11h
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Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| RS4-11 | IC50 |
31.52 nM
Compound: 11h
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Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| U-937 | IC50 |
60.51 nM
Compound: 11h
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Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 34942071] |
In wt-p53 MV4-11 cells, HDAC-IN-27 (11h) leads to pro-caspase-3 cleavage, apparent apoptotic cell death, and accumulation of sub-G1 cell population while inducing G2/M arrest in HL60 cells with no evidence of apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2763368-89-2
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Appearance Solid
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Peso molecular 350.41
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Fòrmula C20H22N4O2
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Color White to off-white
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SMILES
O=C(C1=CC2=CC=CC=C2N1)NCC3=CC=C(C=C3)C(NNCCC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 16.67 mg/mL (47.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8538 mL | 14.2690 mL | 28.5380 mL | 71.3450 mL |
| 5 mM | 0.5708 mL | 2.8538 mL | 5.7076 mL | 14.2690 mL | |
| 10 mM | 0.2854 mL | 1.4269 mL | 2.8538 mL | 7.1345 mL | |
| 15 mM | 0.1903 mL | 0.9513 mL | 1.9025 mL | 4.7563 mL | |
| 20 mM | 0.1427 mL | 0.7134 mL | 1.4269 mL | 3.5672 mL | |
| 25 mM | 0.1142 mL | 0.5708 mL | 1.1415 mL | 2.8538 mL | |
| 30 mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 2.3782 mL | |
| 40 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7836 mL |
HDAC-IN-27 Related Classifications
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