2763368-89-2
Chemical Structure
HDAC-IN-27
- CAS No.: 2763368-89-2
- Formula:C20H22N4O2
- Molecular Weight:350.41
IUPAC Name: N-(4-(2-propylhydrazine-1-carbonyl)benzyl)-1H-indole-2-carboxamide
InChIKey: XGCLYPPRQZTIBB-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CC=C2N1)NCC3=CC=C(C=C3)C(NNCCC)=O
Biological Activity: HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML)[1].
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HDAC-IN-27 | 98.12% | HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML). | ||||||||||||||||||||
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Keywords
