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Cat. No.: HY-146750

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HDAC-IN-37

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HDAC-IN-37 is a potent HDAC inhibitor with IC₅₀s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2766466-56-0
Formula: C₂₃H₂₄ClN₇O
Molecular Weight:449.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

HDAC-IN-37 Chemical Structure

CAS No.: 2766466-56-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC1

55.1 nM (IC₅₀)

HDAC3

1.24 μM (IC₅₀)

HDAC8

0.948 μM (IC₅₀)

HDAC6

34.2 μM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.65 μM Compound: 9d	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
HCT-116	IC₅₀	0.5 μM Compound: 9d	Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
HepG2	IC₅₀	1.29 μM Compound: 9d	Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
K562	IC₅₀	0.12 μM Compound: 9d	Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
MDA-MB-231	IC₅₀	0.38 μM Compound: 9d	Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
SGC-7901	IC₅₀	1.52 μM Compound: 9d	Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay	[PMID: 35041998]

In Vitro

HDAC-IN-37 (compound 9d) exhibits the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC₅₀s of 0.50, 0.38, 0.12 μM, respectively^[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) significantly induces the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells^[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) induces cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis^[1].
HDAC-IN-37 (0 - 10 μM; 6, 12, 24 hours) causes G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression^[1].
HDAC-IN-37 (0, 0.1, 0.5, 1, 5 and 10 μM; 0, 6, 12, 24, 36, 48 hours) down-regulates the levels of CDK2, Cyclin D1 and the up-regulates P21 with dose- and time-dependent manners in HCT-116 cells, and decreases Bcl-2 of Bcl-2 family in dose- and time-dependent manners^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

HCT-116, MDA-MB-231, HepG2, A549, SGC7901 and K562^[1]
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Exhibited the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC₅₀ of 0.50, 0.38, 0.12 μM, respectively.

Western Blot Analysis

Cell Line:

HCT-116^[1]
Concentration:

0, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

24 hours
Result:

Significantly induced the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells.

Apoptosis Analysis

Cell Line:

HCT-116^[1]
Concentration:

0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

24 hours
Result:

Induced cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis.

Cell Cycle Analysis

Cell Line:

HCT-116^[1]
Concentration:

0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

0, 6, 12 and 24 hours
Result:

Caused G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression.

Chemical Information

CAS No. 2766466-56-0
Molecular Weight 449.94
Formula C₂₃H₂₄ClN₇O
SMILES

CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mao PT, He WB, Mai X, et al. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorg Med Chem. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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HDAC-IN-37

Publications Citing Use of MedChemExpress (MCE) HDAC-IN-37

All HDAC Isoforms