2766466-56-0
Chemical Structure
HDAC-IN-37
- CAS No.: 2766466-56-0
- Formula:C23H24ClN7O
- Molecular Weight:449.94
IUPAC Name: N-(2-aminophenyl)-4-((6-(butylamino)-2-chloro-9H-purin-9-yl)methyl)benzamide
InChIKey: UTSVDUQIDLMZLA-UHFFFAOYSA-N
SMILES: CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O
Biological Activity: HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis[1].
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HDAC-IN-37 | HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis. | |||||||||||||||||||||
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Keywords
