1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. CHDI-390576

CHDI-390576 

Cat. No.: HY-119939
Handling Instructions

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

For research use only. We do not sell to patients.

CHDI-390576 Chemical Structure

CHDI-390576 Chemical Structure

CAS No. : 1629729-98-1

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Description

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1].

IC50 & Target[1]

HDAC4

54 nM (IC50)

HDAC5

60 nM (IC50)

HDAC7

31 nM (IC50)

hHDAC9

50 nM (IC50)

HDAC1

39.7 μM (IC50)

HDAC3

25.8 μM (IC50)

HDAC8

9.1 μM (IC50)

hHDAC6

6.2 μM (IC50)

In Vitro

The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM[1].
CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

391.32

Formula

C₁₉H₁₃F₄N₃O₂

CAS No.

1629729-98-1

SMILES

O=C(NO)C(C1=C(F)C=CC=C1)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CHDI-390576
Cat. No.:
HY-119939
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CHDI-390576

Cat. No.: HY-119939