1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. CHDI-390576

CHDI-390576 

Cat. No.: HY-119939 Purity: 99.42%
COA Handling Instructions

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

For research use only. We do not sell to patients.

CHDI-390576 Chemical Structure

CHDI-390576 Chemical Structure

CAS No. : 1629729-98-1

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Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
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25 mg USD 400 In-stock
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50 mg USD 650 In-stock
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100 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1].

IC50 & Target[1]

HDAC4

54 nM (IC50)

HDAC5

60 nM (IC50)

HDAC7

31 nM (IC50)

hHDAC9

50 nM (IC50)

HDAC1

39.7 μM (IC50)

HDAC3

25.8 μM (IC50)

HDAC8

9.1 μM (IC50)

hHDAC6

6.2 μM (IC50)

In Vitro

The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM[1].
CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

391.32

Formula

C19H13F4N3O2

CAS No.
SMILES

O=C(NO)C(C1=C(F)C=CC=C1)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (638.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5555 mL 12.7773 mL 25.5545 mL
5 mM 0.5111 mL 2.5555 mL 5.1109 mL
10 mM 0.2555 mL 1.2777 mL 2.5555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.42%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CHDI-390576
Cat. No.:
HY-119939
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