2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. CHDI-390576

CHDI-390576 

Cat. No.: HY-119939 Purity: 99.42%
COA Handling Instructions

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

For research use only. We do not sell to patients.

CHDI-390576 Chemical Structure

CHDI-390576 Chemical Structure

CAS No. : 1629729-98-1

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Solution
10 mM * 1 mL in DMSO USD 132 In-stock
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10 mM * 1 mL
ready for reconstitution
 USD 132 In-stock
Solid
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10 mg USD 200 In-stock
25 mg USD 400 In-stock
50 mg USD 650 In-stock
100 mg USD 1050 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CHDI-390576 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1].

IC50 & Target[1]

HDAC4

54 nM (IC50)

HDAC5

60 nM (IC50)

HDAC7

31 nM (IC50)

hHDAC9

50 nM (IC50)

HDAC1

39.7 μM (IC50)

HDAC3

25.8 μM (IC50)

HDAC8

9.1 μM (IC50)

hHDAC6

6.2 μM (IC50)

In Vitro

The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM[1].
CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHDI-390576 Related Antibodies
Molecular Weight

391.32

Appearance

Solid

Formula

C19H13F4N3O2
CAS No.
SMILES

O=C(NO)C(C1=C(F)C=CC=C1)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (638.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5555 mL 12.7773 mL 25.5545 mL
5 mM 0.5111 mL 2.5555 mL 5.1109 mL
10 mM 0.2555 mL 1.2777 mL 2.5555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.42%

COA (249 KB) HNMR (274 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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CHDI-390576 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CHDI-3905761629729-98-1CHDI390576CHDI 390576HDACHistone deacetylasesInhibitorinhibitorinhibit

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