HDAC-IN-39
HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2414046-33-4
- Formula: C27H26N4O4S
- Molecular Weight:502.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HDAC1 1.07 μM (IC50) |
HDAC2 1.47 μM (IC50) |
HDAC3 2.27 μM (IC50) |
HDAC8 >10 μM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KB | GI50 |
0.012 μM
Compound: 16c
|
Antiproliferative activity against human KB cells incubated for 48 hrs by SRB assay
Antiproliferative activity against human KB cells incubated for 48 hrs by SRB assay
|
[PMID: 32171161] |
| KB | IC50 |
12 nM
Compound: 20
|
Antiproliferative activity against human KB cells assessed as cell growth inhibition
Antiproliferative activity against human KB cells assessed as cell growth inhibition
|
[PMID: 34101463] |
| KB | IC50 |
12 nM
Compound: 20
|
Antiproliferative activity against vincristine-resistant human KB cells assessed as cell growth inhibition
Antiproliferative activity against vincristine-resistant human KB cells assessed as cell growth inhibition
|
[PMID: 34101463] |
| KB | IC50 |
22 nM
Compound: 20
|
Antiproliferative activity against etoposide-resistant human KB cells assessed as cell growth inhibition
Antiproliferative activity against etoposide-resistant human KB cells assessed as cell growth inhibition
|
[PMID: 34101463] |
Chemical Information
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CAS No. 2414046-33-4
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Molecular Weight 502.58
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Formula C27H26N4O4S
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SMILES
COC1=CC=C(C=C1)S(=O)(NC2=CC=CC=C2NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)