1. Cell Cycle/DNA Damage
    Epigenetics
    Cytoskeleton
    Apoptosis
  2. HDAC
    Microtubule/Tubulin
    Apoptosis
  3. HDAC-IN-39

HDAC-IN-39 

Cat. No.: HY-146392
Handling Instructions

HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells.

For research use only. We do not sell to patients.

HDAC-IN-39 Chemical Structure

HDAC-IN-39 Chemical Structure

CAS No. : 2414046-33-4

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Description

HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells[1].

IC50 & Target

HDAC1

1.07 μM (IC50)

HDAC2

1.47 μM (IC50)

HDAC3

2.27 μM (IC50)

HDAC8

>10 μM (IC50)

Molecular Weight

502.58

Formula

C27H26N4O4S

CAS No.
SMILES

COC1=CC=C(C=C1)S(=O)(NC2=CC=CC=C2NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O)=O

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HDAC-IN-39
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