HDAC-IN-39
Based on 1 publication(s) in Google Scholar
HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2414046-33-4
- 分子式: C27H26N4O4S
- 分子量:502.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 HDAC-IN-39
More
生物活性
製品説明
IC50 & Target
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HDAC1 1.07 μM (IC50) |
HDAC2 1.47 μM (IC50) |
HDAC3 2.27 μM (IC50) |
HDAC8 >10 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | GI50 |
0.012 μM
Compound: 16c
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Antiproliferative activity against human KB cells incubated for 48 hrs by SRB assay
Antiproliferative activity against human KB cells incubated for 48 hrs by SRB assay
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[PMID: 32171161] |
| KB | IC50 |
12 nM
Compound: 20
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Antiproliferative activity against human KB cells assessed as cell growth inhibition
Antiproliferative activity against human KB cells assessed as cell growth inhibition
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[PMID: 34101463] |
| KB | IC50 |
12 nM
Compound: 20
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Antiproliferative activity against vincristine-resistant human KB cells assessed as cell growth inhibition
Antiproliferative activity against vincristine-resistant human KB cells assessed as cell growth inhibition
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[PMID: 34101463] |
| KB | IC50 |
22 nM
Compound: 20
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Antiproliferative activity against etoposide-resistant human KB cells assessed as cell growth inhibition
Antiproliferative activity against etoposide-resistant human KB cells assessed as cell growth inhibition
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[PMID: 34101463] |
化学情報
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CAS 番号 2414046-33-4
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分子量 502.58
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分子式 C27H26N4O4S
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SMILES
COC1=CC=C(C=C1)S(=O)(NC2=CC=CC=C2NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HDAC-IN-39 関連分類
HY-146392 関連分類
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