2414046-33-4
Chemical Structure
HDAC-IN-39
- CAS No.: 2414046-33-4
- Formula:C27H26N4O4S
- Molecular Weight:502.58
IUPAC Name: N-(2-aminophenyl)-4-(((2-((4-methoxyphenyl)sulfonamido)phenyl)amino)methyl)benzamide
InChIKey: HPPZWGKNLWSQRW-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)S(=O)(NC2=CC=CC=C2NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O)=O
Biological Activity: HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells[1].
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HDAC-IN-39 | HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells. | |||||||||||||||||||||
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