2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. MC1742

MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC.

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MC1742 Chemical Structure

MC1742 Chemical Structure

CAS No. : 1776116-74-5

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10 mg USD 250 In-stock
25 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

MC1742 Related Antibodies

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View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC[1].

IC50 & Target[1]

HDAC1

0.1 μM (IC50)

HDAC2

0.11 μM (IC50)

HDAC3

0.02 μM (IC50)

HDAC6

0.007 μM (IC50)

HDAC8

0.61 μM (IC50)

HDAC10

0.04 μM (IC50)

HDAC11

0.1 μM (IC50)

In Vitro

MC1742 (compound 1) (0.5 and 2 μM; 24 hours) increases acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3[1].
MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 hours) significantly induces apoptosis of all CSC cultures[1].
MC1742 (0.025-0.5 μM; 14 days) enhances bone nodule formation in a significant dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC1742 Related Antibodies

Immunofluorescence

Cell Line: Sarcoma cancer stem cells[1]
Concentration: 0.5 and 2 μM
Incubation Time: 24 hours
Result: Increased acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.

Apoptosis Analysis

Cell Line: Sarcoma cancer stem cells[1]
Concentration: 0.5, 1 and 2 μM
Incubation Time: 24, 48 and 72 hours
Result: Significantly induced apoptosis of all CSC cultures.

Cell Differentiation Assay

Cell Line: Sarcoma cancer stem cells[1]
Concentration: 0.025, 0.05, 0.1 and 0.5 μM
Incubation Time: 14 days
Result: Successfully enhanced bone nodule formation in a significant dose-dependent manner.
Molecular Weight

395.47

Formula

C21H21N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)SCCCCC(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (505.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5286 mL 12.6432 mL 25.2864 mL
5 mM 0.5057 mL 2.5286 mL 5.0573 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5286 mL 12.6432 mL 25.2864 mL 63.2159 mL
5 mM 0.5057 mL 2.5286 mL 5.0573 mL 12.6432 mL
10 mM 0.2529 mL 1.2643 mL 2.5286 mL 6.3216 mL
15 mM 0.1686 mL 0.8429 mL 1.6858 mL 4.2144 mL
20 mM 0.1264 mL 0.6322 mL 1.2643 mL 3.1608 mL
25 mM 0.1011 mL 0.5057 mL 1.0115 mL 2.5286 mL
30 mM 0.0843 mL 0.4214 mL 0.8429 mL 2.1072 mL
40 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5804 mL
50 mM 0.0506 mL 0.2529 mL 0.5057 mL 1.2643 mL
60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0536 mL
80 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
100 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6322 mL
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MC1742 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC17421776116-74-5MC 1742MC-1742HDACApoptosisHistone deacetylasesAnticancerSarcoma cancer stem cellsCell differentiationBone nodule formationInhibitorinhibitorinhibit

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