1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. HDAC
    HIV
  3. BRD-6929

BRD-6929 

Cat. No.: HY-100719
Handling Instructions

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1.

For research use only. We do not sell to patients.

BRD-6929 Chemical Structure

BRD-6929 Chemical Structure

CAS No. : 849234-64-6

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Description

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].

IC50 & Target[1][2]

HDAC1

1 nM (IC50)

HDAC2

8 nM (IC50)

HIV

 

Molecular Weight

351.42

Formula

C₁₉H₁₇N₃O₂S

CAS No.

849234-64-6

SMILES

O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BRD-6929BRD6929BRD 6929HDACHIVHistone deacetylasesHuman immunodeficiency virusInhibitorinhibitorinhibit

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BRD-6929
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