Nanatinostat (Synonyms: CHR-3996)

Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC₅₀ of 8 nM^[1].

IC50：8 nM ( HDAC)^[1]

394.40

C₂₀H₁₉FN₆O₂

1256448-47-1

FC1=CC=C2N=C(CN[[email protected]]3[[email protected]]4([H])CN(C5=NC=CC(C(NO)=O)=N5)C[[email protected]]34[H])C=CC2=C1

Room temperature in continental US; may vary elsewhere

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Moffat D, et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J Med Chem. 2010 Dec 23;53(24):8663-78.