PARP-1/HDAC-IN-1
PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities.
For research use only. We do not sell to patients.
- CAS No.: 3032621-10-3
- Formula: C22H18N4O4
- Molecular Weight:402.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP-1 68.90 nM (IC50) |
HDAC6 510 nM (IC50) |
HDAC2 42130 nM (IC50) |
HDAC3 7220 nM (IC50) |
PARP-1/HDAC-IN-1 (Compound 1–8-6) possesses potent inhibitory activity against MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1 cells with IC50 values of 0.35 μM, 1.16 μM, 3.38 μM, 5.67 μM, 2.85 μM, and 4.53 μM, respectively[1].
PARP-1/HDAC-IN-1 (Compound 1–8-6; 0.3-10 μM) is able to heighten expression level of acetylated α-tubulin with marginal effects to acetylated histones H3 and H4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3032621-10-3
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Molecular Weight 402.40
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Formula C22H18N4O4
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SMILES
NC(C1=CC=CC2=CN(N=C21)C3=CC=C(C=C3)OCC4=CC=C(C=C4)C(NO)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP-1/HDAC-IN-1 Related Classifications
HY-146160 Related Classifications
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