1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. BG45

BG45 

Cat. No.: HY-18712 Purity: 99.71 %
Handling Instructions

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM).

For research use only. We do not sell to patients.

BG45 Chemical Structure

BG45 Chemical Structure

CAS No. : 926259-99-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 576 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    BG45 purchased from MCE. Usage Cited in: Oncol Rep. 2018 Apr;39(4):1957-1965.

    Cells are treated with 10 mM Metformin, 10 μM BG45, or the combination of both drugs for 48 h, and then lysates are collected and apoptosis-associated markers are examined via western blot analysis.
    • Biological Activity

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    Description

    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6) Target: HDAC At concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

    IC50 & Target[1]

    HDAC3

    0.289 μM (IC50)

    HDAC1

    2.0 μM (IC50)

    HDAC2

    2.2 μM (IC50)

    Molecular Weight

    214.22

    Formula

    C₁₁H₁₀N₄O

    CAS No.

    926259-99-6

    SMILES

    O=C(C1=NC=CN=C1)NC2=CC=CC=C2N

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 48 mg/mL (224.07 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.6681 mL 23.3405 mL 46.6810 mL
    5 mM 0.9336 mL 4.6681 mL 9.3362 mL
    10 mM 0.4668 mL 2.3340 mL 4.6681 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      BG45 is diluted in natural saline (NS)[2].

    References
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    Product Name:
    BG45
    Cat. No.:
    HY-18712
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