926259-99-6
926259-99-6
Chemical Structure
BG45
- CAS. Nr.: 926259-99-6
- Formula:C11H10N4O
- Molecular Weight:214.22
IUPAC Name: N-(2-aminophenyl)pyrazine-2-carboxamide
InChIKey: LMWPVSNHKACEKW-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CN=C1)NC2=CC=CC=C2N
Biological Activity: BG45 is a potent HDAC3 inhibitor with IC50 values of 0.289, 2, 2.2 and ﹥20 μM for HDAC3, HDAC1, HDAC2 and HDAC6, respectively. BG45 selectively targets multiple myeloma (MM) cells and induces caspase-dependent apoptosis[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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BG45 | 99.95% | BG45 is a potent HDAC3 inhibitor with IC50 values of 0.289, 2, 2.2 and ﹥20 μM for HDAC3, HDAC1, HDAC2 and HDAC6, respectively. BG45 selectively targets multiple myeloma (MM) cells and induces caspase-dependent apoptosis. | ||||||||||||||||||||
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References
- [1]. Minami J, et, al. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma. Leukemia. 2014 Mar;28(3):680-9. [Content Brief]
- [2]. Iaconelli J, et, al. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. ACS Chem Biol. 2015 Mar 20;10(3):883-90. [Content Brief]
