HDAC1/3-IN-1
Based on 1 Customer Validation
HDAC1/3-IN-1 is a selective HDAC1/3 inhibitor, with IC50 values of 256 nM and 340.3 nM against HDAC1 and HDAC3, respectively. HDAC1/3-IN-1 increases the SubG1 cell population and promotes apoptosis of glioma cells and glioblastoma stem cells. HDAC1/3-IN-1 can be used in studies related to glioblastoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.81%
- CAS. Nr.: 244289-53-0
- Formel: C19H17N3O3S
- Molecular Weight:367.42
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
HDAC1 256 nM (IC50) |
HDAC3 340.3 nM (IC50) |
In Vitro
HDAC1/3-IN-1 (Compound 6a) (0.6-50 μM; 24-72 h) inhibits the proliferation of HOG, T98G, U87MG and U251MG glioma cell lines in a time-dependent manner, with the lowest GI50 of 0.6 μM measured in U251MG cells after 72 h of incubation[1].
HDAC1/3-IN-1 (10.8-50 μM; 24 h) inhibits histone H3 deacetylation in HOG, T98G and U251MG glioma cell lines when applied at the relevant concentrations for 24 h[1].
HDAC1/3-IN-1 (10.8-50 μM; 24 h) induces SubG1 phase cell accumulation in aggressive glioma cell lines T98G and U251MG, suggesting the presence of DNA fragmentation and apoptosis, while also modulating the cell cycle phase distribution of the tested glioma cell lines[1].
HDAC1/3-IN-1 (10.8-50 μM; 24 h) induces early apoptosis in glioma cell lines HOG, T98G, U87MG and U251MG[1].
HDAC1/3-IN-1 (72 h) inhibits the viability of mesenchymal (GG16) and proneural (GSC23) glioblastoma stem cell lines, with IC50 values of 2.079 μM and 1.851 μM respectively after 72 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Glioma cell lines HOG, T98G, U87MG, U251MG
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Concentration:50 μM (HOG, T98G, U87MG); 10.8 μM (U251MG)
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Incubation Time:24 h
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Result:Promoted accumulation of acetyl-histone H3 in HOG, T98G, and U251MG cell lines, with comparable effects to positive controls in these cells.
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Cell Line:Glioma cell lines HOG, T98G, U87MG, U251MG
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Concentration:50 μM (T98G); 10.8 μM (U251MG)
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Incubation Time:24 h
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Result:Increased the percentage of cells in the SubG1 phase in T98G and U251MG cell lines.
Modulated cell cycle phase distribution, increasing the G0/G1 phase in HOG cells and modulating the S phase in U87MG cells.
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Cell Line:Glioma cell lines HOG, T98G, U87MG, U251MG
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Concentration:50 μM (HOG, T98G, U87MG); 10.8 μM (U251MG)
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Incubation Time:24 h
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Result:Induced early apoptosis in HOG, T98G, U87MG, and U251MG cell lines.
Chemical Information
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CAS. Nr. 244289-53-0
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Appearance Solid
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Molecular Weight 367.42
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Formel C19H17N3O3S
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Color White to off-white
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SMILES
O=C(NC1=CC=CC=C1N)C2=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (136.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7217 mL | 13.6084 mL | 27.2168 mL | 68.0420 mL |
| 5 mM | 0.5443 mL | 2.7217 mL | 5.4434 mL | 13.6084 mL | |
| 10 mM | 0.2722 mL | 1.3608 mL | 2.7217 mL | 6.8042 mL | |
| 15 mM | 0.1814 mL | 0.9072 mL | 1.8145 mL | 4.5361 mL | |
| 20 mM | 0.1361 mL | 0.6804 mL | 1.3608 mL | 3.4021 mL | |
| 25 mM | 0.1089 mL | 0.5443 mL | 1.0887 mL | 2.7217 mL | |
| 30 mM | 0.0907 mL | 0.4536 mL | 0.9072 mL | 2.2681 mL | |
| 40 mM | 0.0680 mL | 0.3402 mL | 0.6804 mL | 1.7011 mL | |
| 50 mM | 0.0544 mL | 0.2722 mL | 0.5443 mL | 1.3608 mL | |
| 60 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1340 mL | |
| 80 mM | 0.0340 mL | 0.1701 mL | 0.3402 mL | 0.8505 mL | |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2722 mL | 0.6804 mL |
HDAC1/3-IN-1 Related Classifications
HY-181640 Related Classifications
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