2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC HDAC
  4. HDAC3-IN-8

HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

HDAC3-IN-8

HDAC3-IN-8 Chemical Structure

CAS No. : 2763368-90-5

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HDAC3-IN-8 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML)[1].

IC50 & Target[1]

HDAC3

0.38 nM (IC50)

HDAC1

3.52 nM (IC50)

HDAC2

15.14 nM (IC50)

In Vitro

HDAC3-IN-8 (3) exhibits inhibitory activity against HDAC1, HDAC2 and HDAC3 with IC50 values of 3.52 nM, 15.14 nM and 0.38 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC3-IN-8 Related Antibodies
Molecular Weight

351.40

Formula

C20H21N3O3
CAS No.
SMILES

O=C(C1=CC2=CC=CC=C2O1)NCC3=CC=C(C(NNCCC)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC3-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3-IN-82763368-90-5Ligands for Target Protein for PROTACHDACTarget Protein-binding MoietyHistone deacetylasesHDAC1histone deacetylase inhibitorMV4-11 cellsacute myeloid leukemiaHDAC3male ICR miceantileukemic activityHDAC2Inhibitorinhibitorinhibit

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