2763368-90-5
Chemical Structure
HDAC3-IN-8
- CAS No.: 2763368-90-5
- Formula:C20H21N3O3
- Molecular Weight:351.40
InChIKey: JPXOLQFKWRYZSF-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CC=C2O1)NCC3=CC=C(C(NNCCC)=O)C=C3
Biological Activity: HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML)[1].
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HDAC3-IN-8 | HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML). | |||||||||||||||||||||
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Keywords
