2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. HDAC Microtubule/Tubulin
  4. FT108

FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5.

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FT108

FT108 Chemical Structure

CAS No. : 2379645-28-8

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FT108 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5[1].

IC50 & Target[1]

HDAC6

0.026 μM (IC50)

HDAC8

4.07 μM (IC50)

HDAC3

6.68 μM (IC50)

In Vitro

FT108 (0.03-16 μM; 48 h) does not reduce survival of HEL92.1.7, SET-2, JAK2V617F Ba/F3, or MPLW515L Ba/F3 MPN cell lines when treated for 48 hours at concentrations up to 16 μM[1].
FT108 (0.2-1 μM; 24 h) increases ac-tubulin levles but does not alter JAK-STAT signaling pathway activity or acetylated histone H3 levels[1].
FT108 is a highly selective inhibitor of HDAC6 (IC50 = 0.026 μM) with weak cross-reactivity to HDAC3 (IC50 = 6.68 μM) and HDAC8 (IC50 = 4.07 μM) in enzymatic biochemical assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FT108 Related Antibodies

Cell Viability Assay[1]

Cell Line: human HEL92.1.7, human SET-2, mouse JAK2V617 Ba/F3, mouse MPLW515LBa/F3 cells
Concentration: 0.03, 0.06, 0.12, 0.25, 1, 2, 4, 8,16 μM
Incubation Time: 48 h
Result: Lacked activity in all tested MPN cell lines, with cell survival remaining near 100% across all concentrations tested.

Western Blot Analysis[1]

Cell Line: human HEL92.1.7 MPN cells
Concentration: 0.2, 0.5, 1 μM
Incubation Time: 24 h
Result: Caused marked increases in ac-tubulin levels, consistent with effective HDAC6 suppression.
Had little to no effect on acetylated histone H3 levels.
Did not reduce levels of phosphorylated JAK2, phosphorylated STAT3, or phosphorylated STAT5, and had no impact on total JAK2, STAT3, or STAT5 levels.
Molecular Weight

320.34

Formula

C16H20N2O5
CAS No.
SMILES

O=C(C1=CC=C2C(OCCN(C2)C(C3CCOCC3)=O)=C1)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FT108 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FT1082379645-28-8FT 108FT-108HDACMicrotubule/TubulinHistone deacetylasesHEL92.1.7Ba/F3histone H3α-tubulinHDAC6JAK2$^{V617F}$ Ba/F3HDAC3SET-2myeloproliferative neoplasmHDAC8Inhibitorinhibitorinhibit

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