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Art. -Nr.: HY-182720

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FT108

FT108 is a selective HDAC6 inhibitor with an IC₅₀ of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC₅₀ values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5.

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CAS. Nr.: 2379645-28-8
Formel: C₁₆H₂₀N₂O₅
Molecular Weight:320.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

FT108 Chemical Structure

CAS. Nr.: 2379645-28-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HDAC6

0.026 μM (IC₅₀)

HDAC8

4.07 μM (IC₅₀)

HDAC3

6.68 μM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

In Vitro

FT108 (0.03-16 μM; 48 h) does not reduce survival of HEL92.1.7, SET-2, JAK2^V617F Ba/F3, or MPL^W515L Ba/F3 MPN cell lines when treated for 48 hours at concentrations up to 16 μM^[1].
FT108 (0.2-1 μM; 24 h) increases ac-tubulin levles but does not alter JAK-STAT signaling pathway activity or acetylated histone H3 levels^[1].
FT108 is a highly selective inhibitor of HDAC6 (IC₅₀ = 0.026 μM) with weak cross-reactivity to HDAC3 (IC₅₀ = 6.68 μM) and HDAC8 (IC₅₀ = 4.07 μM) in enzymatic biochemical assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human HEL92.1.7, human SET-2, mouse JAK2^V617 Ba/F3, mouse MPL^W515LBa/F3 cells
Concentration:

0.03, 0.06, 0.12, 0.25, 1, 2, 4, 8,16 μM
Incubation Time:

48 h
Result:

Lacked activity in all tested MPN cell lines, with cell survival remaining near 100% across all concentrations tested.

Western Blot Analysis^[1]

Cell Line:

human HEL92.1.7 MPN cells
Concentration:

0.2, 0.5, 1 μM
Incubation Time:

24 h
Result:

Caused marked increases in ac-tubulin levels, consistent with effective HDAC6 suppression.
Had little to no effect on acetylated histone H3 levels.
Did not reduce levels of phosphorylated JAK2, phosphorylated STAT3, or phosphorylated STAT5, and had no impact on total JAK2, STAT3, or STAT5 levels.

Chemical Information

CAS. Nr. 2379645-28-8
Molecular Weight 320.34
Formel C₁₆H₂₀N₂O₅
SMILES

O=C(C1=CC=C2C(OCCN(C2)C(C3CCOCC3)=O)=C1)NO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yue L, et al. HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms. Blood. 2020;135(3):191-207. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
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FT108

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

FT108 Related Classifications

HY-182720 Related Classifications