2379645-28-8
Chemical Structure
FT108
- CAS No.: 2379645-28-8
- Formula:C16H20N2O5
- Molecular Weight:320.34
InChIKey: ZILSXNVUXQNRFE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(OCCN(C2)C(C3CCOCC3)=O)=C1)NO
Biological Activity: FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5[1].
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FT108 | FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5. | |||||||||||||||||||||
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Keywords
