GATA2/3 Antibody (YA2767)
(Synonyms: DCML; GATA binding protein 2; GATA binding protein 3; HDR; HDRS; IMD21; MONOMAC; NFE1B)GATA2/3 Antibody (YA2767) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA2/3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 | 1:50 |
Product Details
GATA2/3 Antibody (YA2767) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA2/3.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Entrez Gene: 2624 Human ; 2625 Human
SwissProt: P23769 Human ; P23771 Human
A synthesized peptide derived from human GATA2/3 aa1-250.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GATA2/3 is a P23769: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'
P23771: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages -
Subcellular Localization
P23769: Nucleus
P23771: Nucleus -
Expression
Tissue_specificity: P23769: Endothelial cells
P23771: T-cells and endothelial cells -
Subunit
P23769: Interacts with BRD3 (By similarity). Interacts with AR and CCAR1. Interacts with MDFIC (By similarity)
P23771: Interacts with TBX21 ('Tyr-530' phosphorylated form) -
Synonyms
DCML; GATA binding protein 2; GATA binding protein 3; HDR; HDRS; IMD21; MONOMAC; NFE1B
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Research Field
Immunology
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