Gfi1 - growth factor independent 1 transcriptional repressor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24388

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of neuron projection development; regulation of cellular biosynthetic process; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; inner ear development; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]

Gfi1 Products (1)

mRNA Protein Name
NM_012566.2 NP_036698.1 zinc finger protein Gfi-1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16287849 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein Gfi-1

  • Growth factor independent-1

  • growth factor independent 1 transcription repressor

  • growth factor independent protein 1

Gfi1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Gfi1 Q07120 Zbtb17 Mus musculus Q60821
Anti Tag CoIP
19164764
Cross
Gfi1 Q07120 ZBTB17 Homo sapiens Q13105-1
Y2H
19164764
Cross
Gfi1 Q07120 ZBTB17 Homo sapiens Q13105-1
Pull Down
19164764
Cross
Gfi1 Q07120 EHMT2 Homo sapiens Q96KQ7
Anti Tag CoIP
16287849
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05378 GFI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183105 DC551040 / Unkown
HY-183202 NCD38 / Unkown
HY-RS05379 GFI1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19335 Gfi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25826 Gfi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfi1 NCBI NCBI:2672