1. Epigenetics
  2. Histone Methyltransferase
  3. BRD4770

BRD4770 

Cat. No.: HY-16705 Purity: 99.87%
Handling Instructions

BRD4770 is a novel G9a(EHMT2) inhibitor with EC50 of 5 uM (trimethylated H3K9 in PANC-1 cell).

For research use only. We do not sell to patients.

BRD4770 Chemical Structure

BRD4770 Chemical Structure

CAS No. : 1374601-40-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 191 In-stock
Estimated Time of Arrival: December 31
10 mg USD 174 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BRD4770 is a novel G9a(EHMT2) inhibitor with EC50 of 5 uM (trimethylated H3K9 in PANC-1 cell). IC50 value: 5 uM (PANC-1 cell) [1] Target: G9a inhibitor BRD4770 activates the ATM pathway without inducing DNA damage, while the ATR pathway is not affected. BRD4770 is a novel probe for studying G9a and its role in cellular senescence.Treatment of 5 μM BRD4770 for 24 h decreased H3K9 trimethylation level by 23% in PANC-1 cells. BRD9539 also inhibits PRC2 activity.

Molecular Weight

413.47

Formula

C₂₅H₂₃N₃O₃

CAS No.

1374601-40-7

SMILES

O=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (13.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4186 mL 12.0928 mL 24.1856 mL
5 mM 0.4837 mL 2.4186 mL 4.8371 mL
10 mM 0.2419 mL 1.2093 mL 2.4186 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.87%

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Product Name:
BRD4770
Cat. No.:
HY-16705
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