CXL 017

Cat. No.: HY-18051: Data Sheet Handling Instructions
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CXL 017 is a sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia.

For research use only. We do not sell to patients.

CXL 017 Chemical Structure

CAS No. : 1063714-11-3

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.49 μM Compound: 5q, CXL017	Cytotoxicity against human DU145 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human DU145 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
HCT-116	IC₅₀	8.83 μM Compound: 5q, CXL017	Cytotoxicity against human HCT116 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human HCT116 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
HL-60	IC₅₀	10.7 μM Compound: 5, CXL017	Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL-60	IC₅₀	10.7 μM Compound: 7c	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay	[PMID: 22582991]
HL-60	IC₅₀	10100 nM Compound: 13; CXL017	Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
HL-60	IC₅₀	5.4 μM Compound: 1; CXL017	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay	[PMID: 26867486]
HL-60	IC₅₀	6.1 μM Compound: 5, (-)-enantiomer	Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL-60	IC₅₀	82.6 μM Compound: 5, (+)-enantiomer	Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL60/MX2	IC₅₀	1.7 μM Compound: 1; CXL017	Cytotoxicity against human HL60/MX2 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay Cytotoxicity against human HL60/MX2 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay	[PMID: 26867486]
HL60/MX2	IC₅₀	1.9 μM Compound: 5, (-)-enantiomer	Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL60/MX2	IC₅₀	2.43 μM Compound: 5, CXL017	Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL60/MX2	IC₅₀	21.8 μM Compound: 5, (+)-enantiomer	Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL60/MX2 cells after 48 hrs by CellTiter-Blue cell viability assay	[PMID: 21780800]
HL60/MX2	IC₅₀	2500 nM Compound: 13; CXL017	Cytotoxicity against human HL60/MX2 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human HL60/MX2 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 37690265]
Jurkat	IC₅₀	1.2 μM Compound: 5q, CXL017	Cytotoxicity against human Jurkat cells after 48 hrs by cell titer-blue assay Cytotoxicity against human Jurkat cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
Jurkat	IC₅₀	1200 nM Compound: 13; CXL017	Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 37690265]
MCF7	IC₅₀	15.48 μM Compound: 5q, CXL017	Cytotoxicity against human MCF7 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human MCF7 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
NALM-6	IC₅₀	4.74 μM Compound: 5q, CXL017	Cytotoxicity against human NALM6 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human NALM6 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
NCI-H460	IC₅₀	5.14 μM Compound: 5q, CXL017	Cytotoxicity against human H460 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human H460 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
REH	IC₅₀	4.16 μM Compound: 5q, CXL017	Cytotoxicity against human REH cells after 48 hrs by cell titer-blue assay Cytotoxicity against human REH cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
SU.86.86	IC₅₀	7.03 μM Compound: 5q, CXL017	Cytotoxicity against human SU-8686 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human SU-8686 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]

Molecular Weight

441.47

Formula

C₂₄H₂₇NO₇

CAS No.

1063714-11-3

SMILES

O=C(C1=C(N)OC2=C(C=C(C3=CC(OC)=CC(OC)=C3)C=C2)C1CC(OCC)=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bleeker NP, et al. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm. 2013 Nov 4;10(11):4358-66. [Content Brief]

CXL 017 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXL 0171063714-11-3CXL017CXL-017Calcium ChannelCa2+ channelsCa channelsSERCAmultidrug-resistantAMLInhibitorinhibitorinhibit

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CXL 017

CXL 017 Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

CXL 017 Related Classifications

Molarity Calculator

Dilution Calculator