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Cat. No.: HY-18051

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CXL 017

CXL 017 is a sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 1063714-11-3
Formula: C₂₄H₂₇NO₇
Molecular Weight:441.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CXL 017 Chemical Structure

CAS No.: 1063714-11-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.49 μM Compound: 5q, CXL017	Cytotoxicity against human DU145 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human DU145 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
HCT-116	IC₅₀	8.83 μM Compound: 5q, CXL017	Cytotoxicity against human HCT116 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human HCT116 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
HL-60	IC₅₀	10.7 μM Compound: 7c	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay	[PMID: 22582991]
HL-60	IC₅₀	5.4 μM Compound: 1; CXL017	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay	[PMID: 26867486]
HL-60	IC₅₀	10100 nM Compound: 13; CXL017	Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
HL60/MX2	IC₅₀	1.7 μM Compound: 1; CXL017	Cytotoxicity against human HL60/MX2 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay Cytotoxicity against human HL60/MX2 cells assessed as cell growth inhibition after 48 hrs by cell titer blue cell viability assay	[PMID: 26867486]
HL60/MX2	IC₅₀	2500 nM Compound: 13; CXL017	Cytotoxicity against human HL60/MX2 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human HL60/MX2 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 37690265]
Jurkat	IC₅₀	1.2 μM Compound: 5q, CXL017	Cytotoxicity against human Jurkat cells after 48 hrs by cell titer-blue assay Cytotoxicity against human Jurkat cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
Jurkat	IC₅₀	1200 nM Compound: 13; CXL017	Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 37690265]
MCF7	IC₅₀	15.48 μM Compound: 5q, CXL017	Cytotoxicity against human MCF7 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human MCF7 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
NALM-6	IC₅₀	4.74 μM Compound: 5q, CXL017	Cytotoxicity against human NALM6 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human NALM6 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
NCI-H460	IC₅₀	5.14 μM Compound: 5q, CXL017	Cytotoxicity against human H460 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human H460 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
REH	IC₅₀	4.16 μM Compound: 5q, CXL017	Cytotoxicity against human REH cells after 48 hrs by cell titer-blue assay Cytotoxicity against human REH cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
SU.86.86	IC₅₀	7.03 μM Compound: 5q, CXL017	Cytotoxicity against human SU-8686 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human SU-8686 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]

Chemical Information

CAS No. 1063714-11-3
Molecular Weight 441.47
Formula C₂₄H₂₇NO₇
SMILES

O=C(C1=C(N)OC2=C(C=C(C3=CC(OC)=CC(OC)=C3)C=C2)C1CC(OCC)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bleeker NP, et al. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm. 2013 Nov 4;10(11):4358-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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CXL 017

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CXL 017 Related Classifications

HY-18051 Related Classifications