GNE - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Also Known as NM; DMRV; IBM2; Uae1; GLCNE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10020

About GNE

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:36,214,441-36,276,978 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and is associated with 7 phenotypes. Broad expression in liver (RPKM 23.5), colon (RPKM 22.5) and 23 other tissues.

Summary

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GNE Products (7)

mRNA	Protein	Name
NM_001128227.3	NP_001121699.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1
NM_001190383.3	NP_001177312.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 4
NM_001190384.3	NP_001177313.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 5
NM_001190388.2	NP_001177317.2	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 3
NM_001374797.1	NP_001361726.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 6
NM_001374798.1	NP_001361727.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 3
NM_005476.7	NP_005467.1	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables N-acylmannosamine kinase activity	IMP IMP: Inferred from mutant phenotype	14707127	GOA
enables UDP-N-acetylglucosamine 2-epimerase activity	IDA IDA: Inferred from direct assay	2808337	GOA
enables UDP-N-acetylglucosamine 2-epimerase activity	IMP IMP: Inferred from mutant phenotype	14707127	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18560563	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CMP-N-acetylneuraminate biosynthetic process	IMP IMP: Inferred from mutant phenotype	31121216	GOA
involved in N-acetylneuraminate biosynthetic process	IMP IMP: Inferred from mutant phenotype	14707127	GOA
involved in glycosylation	IMP IMP: Inferred from mutant phenotype	31121216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNE Protein Structure

Epimerase_2

ROK

0
200
400
600
722 a.a.

Protein Preferred Names	Protein Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	N-acylmannosamine kinase

GNE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNE	Q9Y223	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	GNE	Q9Y223	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	GNE	Q9Y223	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	GNE	Q9Y223	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	25416956
Intra	GNE	Q9Y223	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	GNE	Q9Y223	ACTN1	Homo sapiens	P12814	Anti Tag CoIP	18560563
Intra	GNE	Q9Y223	ACTN1	Homo sapiens	P12814	Pull Down	18560563
Intra	GNE	Q9Y223	ACTN1	Homo sapiens	P12814	SPR	18560563
Intra	GNE	Q9Y223	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	GNE	Q9Y223	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	GNE	Q9Y223	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	25416956
Intra	GNE	Q9Y223	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	25416956
Intra	GNE	Q9Y223	GTPBP3	Homo sapiens	Q969Y2	Y2H Array	25416956
Intra	GNE	Q9Y223	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	GNE	Q9Y223	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	GNE	Q9Y223	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	GNE	Q9Y223	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

GNE Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83172	GNE Antibody (YA2917)	WB, IP	Human
HY-P83172A	GNE Antibody (YA2917)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Nonaka Myopathy	Gne Myopathy Hibm Distal Myopathy With Rimmed Vacuoles Hereditary Inclusion Body Myopathy Ibm2 Inclusion Body Myopathy, Quadriceps-Sparing Qsm Dmrv Distal Myopathy, Nonaka Type Inclusion Body Myopathy 2 Inclusion Body Myopathy, Autosomal Recessive NM Nonaka Distal Myopathy Myopathy, Distal, With Or Without Rimmed Vacuoles Inclusion Body Myopathy, Hereditary, Autosomal Recessive Inclusion Body Myopathy Type 2 Quadriceps-Sparing Myopathy Quadriceps Sparing Myopathy Rimmed Vacuole Myopathy Inclusion Body Myopathy 2, Autosomal Recessive, Formerly Ibm2, Formerly Hibm2 Hereditary Inclusion Body Myopathy Type 2 Inclusion Body Myopathy 2, Autosomal Recessive Myopathy, Distal, With Rimmed Vacuoles Inclusion Body Myopathy Autosomal Recessive Myopathy, Inclusion Body, Type 2 Myopathy, Nonaka
Sialuria	Sialuria, French Type French Type Sialuria Sialuria French Type Sialic Acid Storage Disease Sialic Acid Storage Disease, Finnish Type Infantile Sialic Acid Storage Disease
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Inflammatory Myopathy Myositis, Inclusion Body Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Free Sialic Acid Storage Disorders	Free Sialic Acid Storage Disease Sialic Acid Storage Disease N-Acetylneuraminic Acid Storage Disease Nana Storage Disease Lysosomal Free Sialic Acid Storage Disorders Sialuria, Finnish Type Sialuria Sialic Acid Storage Disease, Finnish Type
Bleeding Disorder, Platelet-Type, 19	Platelet-Type Bleeding Disorder 19 BDPLT19 Severe Autosomal Recessive Macrothrombocytopenia Bleeding Disorder, Platelet Type 19
Miyoshi Muscular Dystrophy	Distal Myopathy Distal Muscular Dystrophy Miyoshi Myopathy Distal Myopathies Dystrophy, Muscular, Miyoshi Myopathy, Distal Distal Muscular Dystrophies
Myopathy	Muscular Diseases Myopathies
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Congenital Disorder Of Glycosylation, Type Iif	CDG2F Congenital Disorder Of Glycosylation Type Iif Cdg Iif Cdgiif Carbohydrate Deficient Glycoprotein Syndrome Type Iif Cmp-Sialic Acid Transporter Deficiency Slc35a1-Cdg Cdg-Iif Cdgiidf Cdg Syndrome Type Iif Congenital Disorder Of Glycosylation Type 2f Congenital Disorder Of Glycosylation 2f Glycosylation, Congenital Disorder Of, Type Iif
Tibial Muscular Dystrophy	Tmd Udd Myopathy Distal Titinopathy Finnish Tibial Muscular Dystrophy Tardive Tibial Muscular Dystrophy Udd Type Distal Myopathy Udd Distal Myopathy Udd-Markesbery Muscular Dystrophy Distal Myopathy, Udd Type Distal Myopathies Tibial Muscular Dystrophy, Tardive
Myopathy, Myofibrillar, 4	Myofibrillar Myopathy 4 MFM4 Zaspopathy Myopathy, Myofibrillar, Zasp-Related
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2	Ibmpfd2 Msp2 Multisystem Proteinopathy 2
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Muscle Tissue Disease
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Muscular Disease
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128850	N-Acetyl-D-mannosamine		99.99%	Phase 2
HY-13246	Apitolisib		99.29%	Phase 2

Pre-clinical Phase

Bioactive Molecules (90)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100742A	(R)-GNE-140	Inhibitor	99.77%	Unkown
HY-147214	GNE-7883	Inhibitor	99.54%	Unkown
HY-108696	GNE-781	Inhibitor	98.51%	Unkown
HY-100343	GNE-495	Inhibitor	99.49%	Unkown
HY-12947	GNE-3511	Inhibitor	99.54%	Unkown
HY-108435	GNE-049	Inhibitor	99.74%	Unkown
HY-129937A	GNE-987	Inhibitor	99.98%	Unkown
HY-158113	CBPD-409	Degrader	99.38%	Unkown
HY-100726	GNE-272	Inhibitor	99.60%	Unkown
HY-15766	GNE-617	Inhibitor	99.58%	Unkown
HY-107986	GNE-6776	Inhibitor	98.03%	Unkown
HY-15796	GNE0877	Inhibitor	99.81%	Unkown
HY-100742	GNE-140 racemate	Inhibitor	99.25%	Unkown
HY-12632	GNE 2861	Inhibitor	98.97%	Unkown
HY-112937	GNE-6640	Inhibitor	99.91%	Unkown
HY-18163	GNE-7915	Inhibitor	99.81%	Unkown
HY-120028	GNE-207	Inhibitor	99.94%	Unkown
HY-12763	GNE-317	Inhibitor	98.76%	Unkown
HY-114332	GNE-8505	Inhibitor	99.53%	Unkown
HY-149026	GNE-064	Inhibitor	99.65%	Unkown
HY-107409	GNE 5729	Agonist	99.05%	Unkown
HY-112803	GNE-371		98.06%	Unkown
HY-19775	GNE-6468	Antagonist	98.02%	Unkown
HY-10811	GNE-493	Inhibitor	99.81%	Unkown
HY-12282	GNE-9605	Inhibitor	99.51%	Unkown
HY-12410	GNE-9822	Inhibitor	98.47%	Unkown
HY-129527	GNE-9278	Modulator	99.91%	Unkown
HY-160821A	N-Acetylmannosamine 6-phosphate sodium salt		95.0%	Unkown
HY-100742B	(S)-GNE-140	Inhibitor	99.30%	Unkown
HY-11042	GNE-477	Inhibitor	98.75%	Unkown
HY-145341	GNE-149	Antagonist	99.18%	Unkown
HY-129939	BET-IN-31	Inhibitor	99.85%	Unkown
HY-112279	GNE-131	Inhibitor	98.15%	Unkown
HY-12628	GNE-618	Inhibitor	99.89%	Unkown
HY-123824	GNE-0439	Inhibitor	99.80%	Unkown
HY-129938	GNE-987 GSH linker-1		98.66%	Unkown
HY-150289	GNE-235		98.86%	Unkown
HY-15883	GNE-900		98.58%	Unkown
HY-19774	GNE-0946	Inhibitor	98.11%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.06%	Unkown
HY-135892	GNE-1858	Inhibitor	99.23%	Unkown
HY-123621	GNE-375	Inhibitor	99.93%	Unkown
HY-10812	GNE-490	Inhibitor	96.79%	Unkown
HY-134592	Piperidine-GNE-049-N-Boc		98.48%	Unkown
HY-107498	GNE-8324	Modulator	98.88%	Unkown
HY-117865	GNE-886	Inhibitor	99.81%	Unkown
HY-149056	GNE-6893	Inhibitor	99.94%	Unkown
HY-162553	GNE7599		99.19%	Unkown
HY-108337	GNE-0723	Agonist	99.93%	Unkown
HY-138634	GNE-987 GSH linker-2	Inhibitor	99.48%	Unkown
HY-128585	GNE684	Inhibitor	99.08%	Unkown
HY-142160	GNE-9815	Inhibitor	98.94%	Unkown
HY-U00428A	GNE 220 hydrochloride	Inhibitor	98.22%	Unkown
HY-107423	GNE 6901	Agonist	99.31%	Unkown
HY-141551	GNE-274	Degrader	98.00%	Unkown
HY-15766A	GNE-617 hydrochloride	Inhibitor	99.16%	Unkown
HY-16983	GNE-3500	Antagonist	98.90%	Unkown
HY-118241	GNE-140	Inhibitor	98.43%	Unkown
HY-148238	GNE-2256	Inhibitor	99.14%	Unkown
HY-149056A	(3S,4R)-GNE-6893	Inhibitor	99.49%	Unkown
HY-RS05551	GNE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00428	GNE 220	Inhibitor	/	Unkown
HY-126291	GNE-616	Inhibitor	/	Unkown
HY-132294	GNE-502	Inhibitor	99.73%	Unkown
HY-101783	GNE-955	Inhibitor	/	Unkown
HY-107409B	(S,S)-GNE 5729		99.65%	Unkown
HY-124153	GNE-431	Inhibitor	/	Unkown
HY-129937	(S)-GNE-987	Inhibitor	/	Unkown
HY-132294A	(1S,3R)-GNE-502	Inhibitor	/	Unkown
HY-13847	GNE-555	Inhibitor	/	Unkown
HY-141551B	(R)-GNE-274		/	Unkown
HY-15882	GNE-783		/	Unkown
HY-16984	GNE-4997	Inhibitor	/	Unkown
HY-174261	KRAS-IN-5	Inhibitor	/	Unkown
HY-175445	GNE-5472		/	Unkown
HY-175447	GDC-0152-amide-PEG2-acid		/	Unkown
HY-175448	GNE-1567		/	Unkown
HY-175449	XIAP ligand 5	Antagonist	/	Unkown
HY-175450	XIAP ligand-Linker Conjugate 2	Antagonist	/	Unkown
HY-176783	GNE-5152	Inhibitor	/	Unkown
HY-182458	GNE-203	Inhibitor	/	Unkown
HY-183817	GNE-781-COOH	Ligand	/	Unkown
HY-100742AR	(R)-GNE-140 (Standard)	Inhibitor	/	Unkown
HY-100742BR	(S)-GNE-140 (Standard)	Inhibitor	/	Unkown
HY-100742R	GNE-140 racemate (Standard)	Inhibitor	/	Unkown
HY-12517	GNE-293	Inhibitor	/	Unkown
HY-182740	GSH linker-2		/	Unkown
HY-185334	GNE-3565	Inhibitor	/	Unkown
HY-RS16774	Gne Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23214	Gne Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GNE	VGNC	VGNC:102936
Mus musculus	GNE	MGD	MGI:1354951
Bos taurus	GNE	VGNC	VGNC:56970
Rattus norvegicus	GNE	RGD	RGD:69239
Canis familiaris	GNE	VGNC	VGNC:51721
Macaca mulatta	GNE	VGNC	VGNC:103269
Others	GNE	NCBI