GNE-375

Cat. No.: HY-123621 Purity: 99.93%: Data Sheet
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GNE-375 is a potent and highly selective BRD9 inhibitor with an IC₅₀ of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin.

For research use only. We do not sell to patients.

GNE-375 Chemical Structure

CAS No. : 1926989-06-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target^[1]

BRD9

5 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
769-P	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human 769-P cells measured after 3 days Cytotoxicity against human 769-P cells measured after 3 days	[PMID: 28606761]
786-0	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human 786-0 cells measured after 3 days Cytotoxicity against human 786-0 cells measured after 3 days	[PMID: 28606761]
A2780	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human A2780 cells measured after 3 days Cytotoxicity against human A2780 cells measured after 3 days	[PMID: 28606761]
A-375	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human A-375 cells measured after 8 days Cytotoxicity against human A-375 cells measured after 8 days	[PMID: 28606761]
A549	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human A549 cells measured after 8 days Cytotoxicity against human A549 cells measured after 8 days	[PMID: 28606761]
ABC-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human ABC-1 cells measured after 8 days Cytotoxicity against human ABC-1 cells measured after 8 days	[PMID: 28606761]
ACHN	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human ACHN cells measured after 3 days Cytotoxicity against human ACHN cells measured after 3 days	[PMID: 28606761]
AMO1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human AMO1 cells measured after 8 days Cytotoxicity against human AMO1 cells measured after 8 days	[PMID: 28606761]
AMO1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human AMO1 cells measured after 3 days Cytotoxicity against human AMO1 cells measured after 3 days	[PMID: 28606761]
AU565	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human AU565 cells measured after 8 days Cytotoxicity against human AU565 cells measured after 8 days	[PMID: 28606761]
AU565	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human AU565 cells measured after 3 days Cytotoxicity against human AU565 cells measured after 3 days	[PMID: 28606761]
BEN	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human BEN cells measured after 8 days Cytotoxicity against human BEN cells measured after 8 days	[PMID: 28606761]
BJAB	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human BJAB cells measured after 8 days Cytotoxicity against human BJAB cells measured after 8 days	[PMID: 28606761]
BJAB	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human BJAB cells measured after 3 days Cytotoxicity against human BJAB cells measured after 3 days	[PMID: 28606761]
BT-20	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human BT-20 cells measured after 3 days Cytotoxicity against human BT-20 cells measured after 3 days	[PMID: 28606761]
BT-474	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human BT-474 cells measured after 3 days Cytotoxicity against human BT-474 cells measured after 3 days	[PMID: 28606761]
BT-549	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human BT-549 cells measured after 8 days Cytotoxicity against human BT-549 cells measured after 8 days	[PMID: 28606761]
CA46	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CA46 cells measured after 8 days Cytotoxicity against human CA46 cells measured after 8 days	[PMID: 28606761]
CA46	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CA46 cells measured after 3 days Cytotoxicity against human CA46 cells measured after 3 days	[PMID: 28606761]
Caco-2	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Caco-2 cells measured after 8 days Cytotoxicity against human Caco-2 cells measured after 8 days	[PMID: 28606761]
CAL-120	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-120 cells measured after 8 days Cytotoxicity against human CAL-120 cells measured after 8 days	[PMID: 28606761]
CAL-12T	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-12T cells measured after 8 days Cytotoxicity against human CAL-12T cells measured after 8 days	[PMID: 28606761]
CAL-12T	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-12T cells measured after 3 days Cytotoxicity against human CAL-12T cells measured after 3 days	[PMID: 28606761]
CAL-148	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-148 cells measured after 3 days Cytotoxicity against human CAL-148 cells measured after 3 days	[PMID: 28606761]
CAL-51	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-51 cells measured after 8 days Cytotoxicity against human CAL-51 cells measured after 8 days	[PMID: 28606761]
CAL-85-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CAL-85-1 cells measured after 3 days Cytotoxicity against human CAL-85-1 cells measured after 3 days	[PMID: 28606761]
Calu-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Calu-1 cells after 8 days Cytotoxicity against human Calu-1 cells after 8 days	[PMID: 28606761]
Calu-3	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Calu-3 cells measured after 8 days Cytotoxicity against human Calu-3 cells measured after 8 days	[PMID: 28606761]
Calu-6	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Calu-6 cells after 8 days Cytotoxicity against human Calu-6 cells after 8 days	[PMID: 28606761]
CAMA-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CAMA-1 cells measured after 8 days Cytotoxicity against human CAMA-1 cells measured after 8 days	[PMID: 28606761]
CAMA-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CAMA-1 cells measured after 3 days Cytotoxicity against human CAMA-1 cells measured after 3 days	[PMID: 28606761]
ChaGo-K-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human ChaGo-K-1 cells measured after 8 days Cytotoxicity against human ChaGo-K-1 cells measured after 8 days	[PMID: 28606761]
CoCM-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human CoCM-1 cells measured after 3 days Cytotoxicity against human CoCM-1 cells measured after 3 days	[PMID: 28606761]
COLO 205	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human COLO 205 cells measured after 8 days Cytotoxicity against human COLO 205 cells measured after 8 days	[PMID: 28606761]
COLO 320	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human COLO 320 cells measured after 8 days Cytotoxicity against human COLO 320 cells measured after 8 days	[PMID: 28606761]
COLO 320DM	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human COLO 320DM cells measured after 8 days Cytotoxicity against human COLO 320DM cells measured after 8 days	[PMID: 28606761]
COLO-678	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human COLO-678 cells measured after 8 days Cytotoxicity against human COLO-678 cells measured after 8 days	[PMID: 28606761]
COLO-741	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human COLO-741 cells measured after 8 days Cytotoxicity against human COLO-741 cells measured after 8 days	[PMID: 28606761]
COR-L47	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human COR-L47 cells measured after 3 days Cytotoxicity against human COR-L47 cells measured after 3 days	[PMID: 28606761]
CW-2	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CW-2 cells measured after 8 days Cytotoxicity against human CW-2 cells measured after 8 days	[PMID: 28606761]
CWR22R	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human 22Rv1 cells after 8 days Cytotoxicity against human 22Rv1 cells after 8 days	[PMID: 28606761]
CX-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human CX-1 cells measured after 8 days Cytotoxicity against human CX-1 cells measured after 8 days	[PMID: 28606761]
DAN-G	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DAN-G cells measured after 8 days Cytotoxicity against human DAN-G cells measured after 8 days	[PMID: 28606761]
Daudi	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Daudi cells measured after 8 days Cytotoxicity against human Daudi cells measured after 8 days	[PMID: 28606761]
Daudi	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Daudi cells measured after 3 days Cytotoxicity against human Daudi cells measured after 3 days	[PMID: 28606761]
DB	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DB cells measured after 8 days Cytotoxicity against human DB cells measured after 8 days	[PMID: 28606761]
DB	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human DB cells measured after 3 days Cytotoxicity against human DB cells measured after 3 days	[PMID: 28606761]
DLD-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DLD-1 cells measured after 8 days Cytotoxicity against human DLD-1 cells measured after 8 days	[PMID: 28606761]
DOHH-2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human DOHH-2 cells measured after 3 days Cytotoxicity against human DOHH-2 cells measured after 3 days	[PMID: 28606761]
DOV13	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human DOV13 cells measured after 3 days Cytotoxicity against human DOV13 cells measured after 3 days	[PMID: 28606761]
DU-145	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DU-145 cells measured after 8 days Cytotoxicity against human DU-145 cells measured after 8 days	[PMID: 28606761]
DU-4475	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DU-4475 cells after 8 days Cytotoxicity against human DU-4475 cells after 8 days	[PMID: 28606761]
DV-90	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human DV-90 cells measured after 8 days Cytotoxicity against human DV-90 cells measured after 8 days	[PMID: 28606761]
EB2	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EB2 cells measured after 8 days Cytotoxicity against human EB2 cells measured after 8 days	[PMID: 28606761]
EB2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EB2 cells measured after 3 days Cytotoxicity against human EB2 cells measured after 3 days	[PMID: 28606761]
EB-3	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EB-3 cells measured after 8 days Cytotoxicity against human EB-3 cells measured after 8 days	[PMID: 28606761]
EB-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EB-3 cells measured after 3 days Cytotoxicity against human EB-3 cells measured after 3 days	[PMID: 28606761]
EBC-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EBC-1 cells after 8 days Cytotoxicity against human EBC-1 cells after 8 days	[PMID: 28606761]
EFM-19	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EFM-19 cells measured after 3 days Cytotoxicity against human EFM-19 cells measured after 3 days	[PMID: 28606761]
EFO-27	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EFO-27 cells measured after 3 days Cytotoxicity against human EFO-27 cells measured after 3 days	[PMID: 28606761]
EJM	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EJM cells measured after 3 days Cytotoxicity against human EJM cells measured after 3 days	[PMID: 28606761]
EKVX	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EKVX cells after 8 days Cytotoxicity against human EKVX cells after 8 days	[PMID: 28606761]
EOL1	IC₅₀	1.34 μM Compound: 11; GNE-375	Cytotoxicity against human EOL1 cells measured after 8 days Cytotoxicity against human EOL1 cells measured after 8 days	[PMID: 28606761]
EOL1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human EOL1 cells measured after 3 days Cytotoxicity against human EOL1 cells measured after 3 days	[PMID: 28606761]
EPLC-272H	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EPLC-272H cells measured after 8 days Cytotoxicity against human EPLC-272H cells measured after 8 days	[PMID: 28606761]
ES-2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human ES2 cells measured after 3 days Cytotoxicity against human ES2 cells measured after 3 days	[PMID: 28606761]
EVSA-T	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human EVSA-T cells measured after 8 days Cytotoxicity against human EVSA-T cells measured after 8 days	[PMID: 28606761]
G-402	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human G-402 cells measured after 3 days Cytotoxicity against human G-402 cells measured after 3 days	[PMID: 28606761]
GA-10	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human GA-10 cells measured after 8 days Cytotoxicity against human GA-10 cells measured after 8 days	[PMID: 28606761]
GP5d	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human GP5d cells measured after 8 days Cytotoxicity against human GP5d cells measured after 8 days	[PMID: 28606761]
Granta-519	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Granta-519 cells measured after 8 days Cytotoxicity against human Granta-519 cells measured after 8 days	[PMID: 28606761]
Granta-519	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Granta-519 cells measured after 3 days Cytotoxicity against human Granta-519 cells measured after 3 days	[PMID: 28606761]
GTL 16 cell line	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human GTL 16 cell line measured after 8 days Cytotoxicity against human GTL 16 cell line measured after 8 days	[PMID: 28606761]
HBL-100	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HBL-100 cells measured after 8 days Cytotoxicity against human HBL-100 cells measured after 8 days	[PMID: 28606761]
HBL-100	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HBL-100 cells measured after 3 days Cytotoxicity against human HBL-100 cells measured after 3 days	[PMID: 28606761]
HCC1143	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1143 cells measured after 8 days Cytotoxicity against human HCC1143 cells measured after 8 days	[PMID: 28606761]
HCC1143	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1143 cells measured after 3 days Cytotoxicity against human HCC1143 cells measured after 3 days	[PMID: 28606761]
HCC1187	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1187 cells measured after 3 days Cytotoxicity against human HCC1187 cells measured after 3 days	[PMID: 28606761]
HCC1395	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1395 cells measured after 8 days Cytotoxicity against human HCC1395 cells measured after 8 days	[PMID: 28606761]
HCC1395	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1395 cells measured after 3 days Cytotoxicity against human HCC1395 cells measured after 3 days	[PMID: 28606761]
HCC1419	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1419 cells measured after 8 days Cytotoxicity against human HCC1419 cells measured after 8 days	[PMID: 28606761]
HCC1419	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1419 cells measured after 3 days Cytotoxicity against human HCC1419 cells measured after 3 days	[PMID: 28606761]
HCC1806	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1806 cells measured after 8 days Cytotoxicity against human HCC1806 cells measured after 8 days	[PMID: 28606761]
HCC1937	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1937 cells measured after 8 days Cytotoxicity against human HCC1937 cells measured after 8 days	[PMID: 28606761]
HCC1954	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1954 cells measured after 8 days Cytotoxicity against human HCC1954 cells measured after 8 days	[PMID: 28606761]
HCC1954	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1954 cells measured after 3 days Cytotoxicity against human HCC1954 cells measured after 3 days	[PMID: 28606761]
HCC2935	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC2935 cells after 8 days Cytotoxicity against human HCC2935 cells after 8 days	[PMID: 28606761]
HCC38	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC38 cells measured after 8 days Cytotoxicity against human HCC38 cells measured after 8 days	[PMID: 28606761]
HCC4006	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC4006 cells measured after 8 days Cytotoxicity against human HCC4006 cells measured after 8 days	[PMID: 28606761]
HCC4017	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC4017 cells measured after 8 days Cytotoxicity against human HCC4017 cells measured after 8 days	[PMID: 28606761]
HCC44	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC44 cells measured after 8 days Cytotoxicity against human HCC44 cells measured after 8 days	[PMID: 28606761]
HCC515	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC515 cells measured after 8 days Cytotoxicity against human HCC515 cells measured after 8 days	[PMID: 28606761]
HCC70	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC70 cells measured after 8 days Cytotoxicity against human HCC70 cells measured after 8 days	[PMID: 28606761]
HCC70	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC70 cells measured after 3 days Cytotoxicity against human HCC70 cells measured after 3 days	[PMID: 28606761]
HCC78	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC78 cells measured after 8 days Cytotoxicity against human HCC78 cells measured after 8 days	[PMID: 28606761]
HCC827	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC827 cells measured after 8 days Cytotoxicity against human HCC827 cells measured after 8 days	[PMID: 28606761]
HCC95	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC95 cells measured after 8 days Cytotoxicity against human HCC95 cells measured after 8 days	[PMID: 28606761]
HCC95	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HCC95 cells measured after 3 days Cytotoxicity against human HCC95 cells measured after 3 days	[PMID: 28606761]
HCT-116	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCT-116 cells measured after 8 days Cytotoxicity against human HCT-116 cells measured after 8 days	[PMID: 28606761]
HCT-15	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCT-15 cells measured after 8 days Cytotoxicity against human HCT-15 cells measured after 8 days	[PMID: 28606761]
HDQ-P1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HDQ-P1 cells measured after 8 days Cytotoxicity against human HDQ-P1 cells measured after 8 days	[PMID: 28606761]
HEL	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HEL cells measured after 8 days Cytotoxicity against human HEL cells measured after 8 days	[PMID: 28606761]
HEL	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HEL cells measured after 3 days Cytotoxicity against human HEL cells measured after 3 days	[PMID: 28606761]
Hep 3B2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Hep 3B2.1-7 cells measured after 3 days Cytotoxicity against human Hep 3B2.1-7 cells measured after 3 days	[PMID: 28606761]
HepG2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HepG2 cells measured after 3 days Cytotoxicity against human HepG2 cells measured after 3 days	[PMID: 28606761]
HEY	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HEY cells measured after 8 days Cytotoxicity against human HEY cells measured after 8 days	[PMID: 28606761]
HEY	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HEY cells measured after 3 days Cytotoxicity against human HEY cells measured after 3 days	[PMID: 28606761]
HLE	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HLE cells measured after 3 days Cytotoxicity against human HLE cells measured after 3 days	[PMID: 28606761]
HMEC	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against HMEC cells measured after 8 days Cytotoxicity against HMEC cells measured after 8 days	[PMID: 28606761]
HOP-62	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HOP-62 cells measured after 8 days Cytotoxicity against human HOP-62 cells measured after 8 days	[PMID: 28606761]
HOP-92	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HOP-92 cells measured after 8 days Cytotoxicity against human HOP-92 cells measured after 8 days	[PMID: 28606761]
HPAC	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HPAC cells measured after 8 days Cytotoxicity against human HPAC cells measured after 8 days	[PMID: 28606761]
Hs 294T	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Hs294T cells measured after 8 days Cytotoxicity against human Hs294T cells measured after 8 days	[PMID: 28606761]
Hs-578T	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Hs-578T cells measured after 8 days Cytotoxicity against human Hs-578T cells measured after 8 days	[PMID: 28606761]
HT	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HT cells measured after 8 days Cytotoxicity against human HT cells measured after 8 days	[PMID: 28606761]
HT	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HT cells measured after 3 days Cytotoxicity against human HT cells measured after 3 days	[PMID: 28606761]
HT-29	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HT-29 cells measured after 8 days Cytotoxicity against human HT-29 cells measured after 8 days	[PMID: 28606761]
HuCCT-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human HuCCT-1 cells measured after 3 days Cytotoxicity against human HuCCT-1 cells measured after 3 days	[PMID: 28606761]
Huh-7	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Huh-7 cells measured after 3 days Cytotoxicity against human Huh-7 cells measured after 3 days	[PMID: 28606761]
IGR-37 cell line	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human IGR-37 cell line measured after 8 days Cytotoxicity against human IGR-37 cell line measured after 8 days	[PMID: 28606761]
IGROV-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human IGROV-1 cells measured after 8 days Cytotoxicity against human IGROV-1 cells measured after 8 days	[PMID: 28606761]
IGROV-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human IGROV-1 cells measured after 3 days Cytotoxicity against human IGROV-1 cells measured after 3 days	[PMID: 28606761]
IMR-32	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human IMR-32 cells measured after 3 days Cytotoxicity against human IMR-32 cells measured after 3 days	[PMID: 28606761]
JeKo-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human JeKo-1 cells measured after 8 days Cytotoxicity against human JeKo-1 cells measured after 8 days	[PMID: 28606761]
JeKo-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human JeKo-1 cells measured after 3 days Cytotoxicity against human JeKo-1 cells measured after 3 days	[PMID: 28606761]
JIMT-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human JIMT-1 cells measured after 8 days Cytotoxicity against human JIMT-1 cells measured after 8 days	[PMID: 28606761]
JIYOYE	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human JIYOYE cells measured after 3 days Cytotoxicity against human JIYOYE cells measured after 3 days	[PMID: 28606761]
JJN-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human JJN-3 cells measured after 3 days Cytotoxicity against human JJN-3 cells measured after 3 days	[PMID: 28606761]
Jurkat	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Jurkat cells measured after 3 days Cytotoxicity against human Jurkat cells measured after 3 days	[PMID: 28606761]
K562	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human K562 cells measured after 8 days Cytotoxicity against human K562 cells measured after 8 days	[PMID: 28606761]
K562	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human K562 cells measured after 3 days Cytotoxicity against human K562 cells measured after 3 days	[PMID: 28606761]
KARPAS-422	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human KARPAS-422 cells measured after 8 days Cytotoxicity against human KARPAS-422 cells measured after 8 days	[PMID: 28606761]
KARPAS-422	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KARPAS-422 cells measured after 3 days Cytotoxicity against human KARPAS-422 cells measured after 3 days	[PMID: 28606761]
KG-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KG-1 cells measured after 3 days Cytotoxicity against human KG-1 cells measured after 3 days	[PMID: 28606761]
KMM-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human KMM-1 cells measured after 8 days Cytotoxicity against human KMM-1 cells measured after 8 days	[PMID: 28606761]
KMM-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KMM-1 cells measured after 3 days Cytotoxicity against human KMM-1 cells measured after 3 days	[PMID: 28606761]
KMS-11	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KMS-11 cells measured after 3 days Cytotoxicity against human KMS-11 cells measured after 3 days	[PMID: 28606761]
KMS-12-BM	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KMS-12-BM cells measured after 3 days Cytotoxicity against human KMS-12-BM cells measured after 3 days	[PMID: 28606761]
KMS-12-PE	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KMS-12-PE cells measured after 3 days Cytotoxicity against human KMS-12-PE cells measured after 3 days	[PMID: 28606761]
KNS-62	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human KNS-62 cells measured after 8 days Cytotoxicity against human KNS-62 cells measured after 8 days	[PMID: 28606761]
KP-4	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human KP-4 cells measured after 8 days Cytotoxicity against human KP-4 cells measured after 8 days	[PMID: 28606761]
KU812 cell line	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human KU812 cell line measured after 3 days Cytotoxicity against human KU812 cell line measured after 3 days	[PMID: 28606761]
L-363	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human L-363 cells measured after 3 days Cytotoxicity against human L-363 cells measured after 3 days	[PMID: 28606761]
LCLC-103H cell line	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LCLC-103H cell line measured after 8 days Cytotoxicity against human LCLC-103H cell line measured after 8 days	[PMID: 28606761]
LCLC-97TM1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LCLC-97TM1 cells measured after 8 days Cytotoxicity against human LCLC-97TM1 cells measured after 8 days	[PMID: 28606761]
LN-18	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human LN-18 cells measured after 3 days Cytotoxicity against human LN-18 cells measured after 3 days	[PMID: 28606761]
LN-229	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human LN-229 cells measured after 3 days Cytotoxicity against human LN-229 cells measured after 3 days	[PMID: 28606761]
LNCaP	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LNCaP clone FGC cells measured after 8 days Cytotoxicity against human LNCaP clone FGC cells measured after 8 days	[PMID: 28606761]
LNCaP	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LNCaP/Ner cells measured after 8 days Cytotoxicity against human LNCaP/Ner cells measured after 8 days	[PMID: 28606761]
LoVo	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LoVo cells measured after 8 days Cytotoxicity against human LoVo cells measured after 8 days	[PMID: 28606761]
LP-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LP-1 cells measured after 8 days Cytotoxicity against human LP-1 cells measured after 8 days	[PMID: 28606761]
LP-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human LP-1 cells measured after 3 days Cytotoxicity against human LP-1 cells measured after 3 days	[PMID: 28606761]
LS-1034	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LS1034 cells measured after 8 days Cytotoxicity against human LS1034 cells measured after 8 days	[PMID: 28606761]
LS180	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LS180 cells measured after 8 days Cytotoxicity against human LS180 cells measured after 8 days	[PMID: 28606761]
LXF-289 cell line	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human LXF-289 cell line measured after 8 days Cytotoxicity against human LXF-289 cell line measured after 8 days	[PMID: 28606761]
MC116	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MC116 cells measured after 8 days Cytotoxicity against human MC116 cells measured after 8 days	[PMID: 28606761]
MC116	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MC116 cells measured after 3 days Cytotoxicity against human MC116 cells measured after 3 days	[PMID: 28606761]
MCF-10A	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MCF-10A cells measured after 3 days Cytotoxicity against human MCF-10A cells measured after 3 days	[PMID: 28606761]
MCF7	IC₅₀	1.34 μM Compound: 11; GNE-375	Cytotoxicity against human MCF7 cells measured after 8 days Cytotoxicity against human MCF7 cells measured after 8 days	[PMID: 28606761]
MCF7	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MCF-7-SER cells measured after 8 days Cytotoxicity against human MCF-7-SER cells measured after 8 days	[PMID: 28606761]
MDA-MB-157	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-157 cells measured after 8 days Cytotoxicity against human MDA-MB-157 cells measured after 8 days	[PMID: 28606761]
MDA-MB-175-VII	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-175-VII cells measured after 3 days Cytotoxicity against human MDA-MB-175-VII cells measured after 3 days	[PMID: 28606761]
MDA-MB-231	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-231 cells measured after 8 days Cytotoxicity against human MDA-MB-231 cells measured after 8 days	[PMID: 28606761]
MDA-MB-361	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-361 cells measured after 3 days Cytotoxicity against human MDA-MB-361 cells measured after 3 days	[PMID: 28606761]
MDA-MB-415	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-415 cells measured after 8 days Cytotoxicity against human MDA-MB-415 cells measured after 8 days	[PMID: 28606761]
MDA-MB-436	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-436 cells measured after 8 days Cytotoxicity against human MDA-MB-436 cells measured after 8 days	[PMID: 28606761]
MDA-MB-453	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-453 cells measured after 3 days Cytotoxicity against human MDA-MB-453 cells measured after 3 days	[PMID: 28606761]
MDA-MB-468	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MDA-MB-468 cells measured after 8 days Cytotoxicity against human MDA-MB-468 cells measured after 8 days	[PMID: 28606761]
MEL-HO	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MEL-HO cells measured after 8 days Cytotoxicity against human MEL-HO cells measured after 8 days	[PMID: 28606761]
MEL-HO	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MEL-HO cells measured after 3 days Cytotoxicity against human MEL-HO cells measured after 3 days	[PMID: 28606761]
MEL-JUSO	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MEL-JUSO cells measured after 8 days Cytotoxicity against human MEL-JUSO cells measured after 8 days	[PMID: 28606761]
MFM-223	IC₅₀	1.46 μM Compound: 11; GNE-375	Cytotoxicity against human MFM-223 cells measured after 8 days Cytotoxicity against human MFM-223 cells measured after 8 days	[PMID: 28606761]
MFM-223	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MFM-223 cells measured after 3 days Cytotoxicity against human MFM-223 cells measured after 3 days	[PMID: 28606761]
MHH-PREB-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MHH-PREB-1 cells measured after 8 days Cytotoxicity against human MHH-PREB-1 cells measured after 8 days	[PMID: 28606761]
MHH-PREB-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MHH-PREB-1 cells measured after 3 days Cytotoxicity against human MHH-PREB-1 cells measured after 3 days	[PMID: 28606761]
MKN-45	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MKN-45 cells measured after 8 days Cytotoxicity against human MKN-45 cells measured after 8 days	[PMID: 28606761]
ML-2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human ML-2 cells measured after 3 days Cytotoxicity against human ML-2 cells measured after 3 days	[PMID: 28606761]
MOLM-13	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MOLM-13 cells measured after 3 days Cytotoxicity against human MOLM-13 cells measured after 3 days	[PMID: 28606761]
MOLM-16	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MOLM16 cells measured after 8 days Cytotoxicity against human MOLM16 cells measured after 8 days	[PMID: 28606761]
MOLM-16	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MOLM16 cells measured after 3 days Cytotoxicity against human MOLM16 cells measured after 3 days	[PMID: 28606761]
MOLP-8	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MOLP8 cells measured after 3 days Cytotoxicity against human MOLP8 cells measured after 3 days	[PMID: 28606761]
MV4-11	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MV4-11 cells measured after 8 days Cytotoxicity against human MV4-11 cells measured after 8 days	[PMID: 28606761]
MX1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human MX1 cells measured after 8 days Cytotoxicity against human MX1 cells measured after 8 days	[PMID: 28606761]
MX1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human MX1 cells measured after 3 days Cytotoxicity against human MX1 cells measured after 3 days	[PMID: 28606761]
NALM-6	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NALM-6 cells measured after 3 days Cytotoxicity against human NALM-6 cells measured after 3 days	[PMID: 28606761]
NAMALVA	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NAMALVA cells measured after 8 days Cytotoxicity against human NAMALVA cells measured after 8 days	[PMID: 28606761]
NAMALVA	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NAMALVA cells measured after 3 days Cytotoxicity against human NAMALVA cells measured after 3 days	[PMID: 28606761]
NCI-H1155	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1155 cells measured after 8 days Cytotoxicity against human NCI-H1155 cells measured after 8 days	[PMID: 28606761]
NCI-H1299	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1299 cells measured after 8 days Cytotoxicity against human NCI-H1299 cells measured after 8 days	[PMID: 28606761]
NCI-H1355	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1355 cells measured after 8 days Cytotoxicity against human NCI-H1355 cells measured after 8 days	[PMID: 28606761]
NCI-H1437	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1437 cells measured after 8 days Cytotoxicity against human NCI-H1437 cells measured after 8 days	[PMID: 28606761]
NCI-H146	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H146 cells measured after 8 days Cytotoxicity against human NCI-H146 cells measured after 8 days	[PMID: 28606761]
NCI-H1573	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1573 cells after 8 days Cytotoxicity against human NCI-H1573 cells after 8 days	[PMID: 28606761]
NCI-H1581	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1581 cells measured after 8 days Cytotoxicity against human NCI-H1581 cells measured after 8 days	[PMID: 28606761]
NCI-H1651	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1651 cells measured after 8 days Cytotoxicity against human NCI-H1651 cells measured after 8 days	[PMID: 28606761]
NCI-H1666	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1666 cells measured after 8 days Cytotoxicity against human NCI-H1666 cells measured after 8 days	[PMID: 28606761]
NCI-H1703	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1703 cells measured after 8 days Cytotoxicity against human NCI-H1703 cells measured after 8 days	[PMID: 28606761]
NCI-H1734	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1734 cells measured after 3 days Cytotoxicity against human NCI-H1734 cells measured after 3 days	[PMID: 28606761]
NCI-H1770	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human HCC1770 cells measured after 8 days Cytotoxicity against human HCC1770 cells measured after 8 days	[PMID: 28606761]
NCI-H1793	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1793 cells measured after 8 days Cytotoxicity against human NCI-H1793 cells measured after 8 days	[PMID: 28606761]
NCI-H1838	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1838 cells measured after 8 days Cytotoxicity against human NCI-H1838 cells measured after 8 days	[PMID: 28606761]
NCI-H1944	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1944 cells measured after 8 days Cytotoxicity against human NCI-H1944 cells measured after 8 days	[PMID: 28606761]
NCI-H1944	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1944 cells measured after 3 days Cytotoxicity against human NCI-H1944 cells measured after 3 days	[PMID: 28606761]
NCI-H1975	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1975 cells measured after 8 days Cytotoxicity against human NCI-H1975 cells measured after 8 days	[PMID: 28606761]
NCI-H1993	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H1993 cells measured after 8 days Cytotoxicity against human NCI-H1993 cells measured after 8 days	[PMID: 28606761]
NCI-H2009	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2009 cells measured after 8 days Cytotoxicity against human NCI-H2009 cells measured after 8 days	[PMID: 28606761]
NCI-H2030	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2030 cells measured after 8 days Cytotoxicity against human NCI-H2030 cells measured after 8 days	[PMID: 28606761]
NCI-H2122	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2122 cells measured after 8 days Cytotoxicity against human NCI-H2122 cells measured after 8 days	[PMID: 28606761]
NCI-H2170	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2170 cells measured after 3 days Cytotoxicity against human NCI-H2170 cells measured after 3 days	[PMID: 28606761]
NCI-H2228	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2228 cells measured after 8 days Cytotoxicity against human NCI-H2228 cells measured after 8 days	[PMID: 28606761]
NCI-H226	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H226 cells measured after 8 days Cytotoxicity against human NCI-H226 cells measured after 8 days	[PMID: 28606761]
NCI-H23	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H23 cells measured after 8 days Cytotoxicity against human NCI-H23 cells measured after 8 days	[PMID: 28606761]
NCI-H2347	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2347 cells measured after 8 days Cytotoxicity against human NCI-H2347 cells measured after 8 days	[PMID: 28606761]
NCI-H2405	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2405 cells measured after 8 days Cytotoxicity against human NCI-H2405 cells measured after 8 days	[PMID: 28606761]
NCI-H2444	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2444 cells measured after 3 days Cytotoxicity against human NCI-H2444 cells measured after 3 days	[PMID: 28606761]
NCI-H2452	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H2452 cells measured after 8 days Cytotoxicity against human NCI-H2452 cells measured after 8 days	[PMID: 28606761]
NCI-H28	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H28 cells measured after 8 days Cytotoxicity against human NCI-H28 cells measured after 8 days	[PMID: 28606761]
NCI-H292	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H292 cells measured after 8 days Cytotoxicity against human NCI-H292 cells measured after 8 days	[PMID: 28606761]
NCI-H358	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H358 cells measured after 8 days Cytotoxicity against human NCI-H358 cells measured after 8 days	[PMID: 28606761]
NCI-H441	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H441 cells measured after 8 days Cytotoxicity against human NCI-H441 cells measured after 8 days	[PMID: 28606761]
NCI-H460	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H460 cells measured after 8 days Cytotoxicity against human NCI-H460 cells measured after 8 days	[PMID: 28606761]
NCI-H460	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H460 cells measured after 3 days Cytotoxicity against human NCI-H460 cells measured after 3 days	[PMID: 28606761]
NCI-H520	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H520 cells measured after 8 days Cytotoxicity against human NCI-H520 cells measured after 8 days	[PMID: 28606761]
NCI-H520	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H520 cells measured after 3 days Cytotoxicity against human NCI-H520 cells measured after 3 days	[PMID: 28606761]
NCI-H522	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H522 cells measured after 8 days Cytotoxicity against human NCI-H522 cells measured after 8 days	[PMID: 28606761]
NCI-H647	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H647 cells measured after 8 days Cytotoxicity against human NCI-H647 cells measured after 8 days	[PMID: 28606761]
NCI-H647	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H647 cells measured after 3 days Cytotoxicity against human NCI-H647 cells measured after 3 days	[PMID: 28606761]
NCI-H650	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H650 cells measured after 8 days Cytotoxicity against human NCI-H650 cells measured after 8 days	[PMID: 28606761]
NCI-H661	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H661 cells measured after 8 days Cytotoxicity against human NCI-H661 cells measured after 8 days	[PMID: 28606761]
NCI-H727	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H727 cells measured after 8 days Cytotoxicity against human NCI-H727 cells measured after 8 days	[PMID: 28606761]
NCI-H82	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H82 cells measured after 8 days Cytotoxicity against human NCI-H82 cells measured after 8 days	[PMID: 28606761]
NCI-H929	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NCI-H929 cells measured after 3 days Cytotoxicity against human NCI-H929 cells measured after 3 days	[PMID: 28606761]
NOMO-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human NOMO-1 cells measured after 3 days Cytotoxicity against human NOMO-1 cells measured after 3 days	[PMID: 28606761]
NUGC-4	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human NUGC-4 cells measured after 8 days Cytotoxicity against human NUGC-4 cells measured after 8 days	[PMID: 28606761]
OAW-28	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OAW28 cells measured after 3 days Cytotoxicity against human OAW28 cells measured after 3 days	[PMID: 28606761]
OAW-42	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OAW-42 cells measured after 3 days Cytotoxicity against human OAW-42 cells measured after 3 days	[PMID: 28606761]
OCI-AML2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OCI-AML2 cells measured after 3 days Cytotoxicity against human OCI-AML2 cells measured after 3 days	[PMID: 28606761]
OCI-AML-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OCI-AML-3 cells measured after 3 days Cytotoxicity against human OCI-AML-3 cells measured after 3 days	[PMID: 28606761]
OCI-AML-5	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human OCI-AML5 cells measured after 8 days Cytotoxicity against human OCI-AML5 cells measured after 8 days	[PMID: 28606761]
OCI-AML-5	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OCI-AML5 cells measured after 3 days Cytotoxicity against human OCI-AML5 cells measured after 3 days	[PMID: 28606761]
OCI-LY19	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human OCILY19 cells measured after 8 days Cytotoxicity against human OCILY19 cells measured after 8 days	[PMID: 28606761]
OCI-LY19	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OCILY19 cells measured after 3 days Cytotoxicity against human OCILY19 cells measured after 3 days	[PMID: 28606761]
ONS-76	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human ONS-76 cells measured after 8 days Cytotoxicity against human ONS-76 cells measured after 8 days	[PMID: 28606761]
OPM-2	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human OPM-2 cells measured after 8 days Cytotoxicity against human OPM-2 cells measured after 8 days	[PMID: 28606761]
OPM-2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OPM-2 cells measured after 3 days Cytotoxicity against human OPM-2 cells measured after 3 days	[PMID: 28606761]
OV-90	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OV-90 cells measured after 3 days Cytotoxicity against human OV-90 cells measured after 3 days	[PMID: 28606761]
OVCAR-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OVCAR-3 cells measured after 3 days Cytotoxicity against human OVCAR-3 cells measured after 3 days	[PMID: 28606761]
OVCAR-4	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OVCAR-4 cells measured after 3 days Cytotoxicity against human OVCAR-4 cells measured after 3 days	[PMID: 28606761]
OVCAR-5	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OVCAR-5 cells measured after 3 days Cytotoxicity against human OVCAR-5 cells measured after 3 days	[PMID: 28606761]
OVCAR-8	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human OVCAR-8 cells measured after 3 days Cytotoxicity against human OVCAR-8 cells measured after 3 days	[PMID: 28606761]
PA-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human PA-1 cells measured after 8 days Cytotoxicity against human PA-1 cells measured after 8 days	[PMID: 28606761]
PA-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human PA-1 cells measured after 3 days Cytotoxicity against human PA-1 cells measured after 3 days	[PMID: 28606761]
PC-3	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human PC-3 cells measured after 8 days Cytotoxicity against human PC-3 cells measured after 8 days	[PMID: 28606761]
PC-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human PC-3 cells measured after 3 days Cytotoxicity against human PC-3 cells measured after 3 days	[PMID: 28606761]
PEO1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human PEO1 cells measured after 3 days Cytotoxicity against human PEO1 cells measured after 3 days	[PMID: 28606761]
PLC-PRF-5	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human PLC-PRF-5 cells measured after 3 days Cytotoxicity against human PLC-PRF-5 cells measured after 3 days	[PMID: 28606761]
Raji	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Raji cells measured after 8 days Cytotoxicity against human Raji cells measured after 8 days	[PMID: 28606761]
Raji	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Raji cells measured after 3 days Cytotoxicity against human Raji cells measured after 3 days	[PMID: 28606761]
Ramos	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human Ramos cells measured after 8 days Cytotoxicity against human Ramos cells measured after 8 days	[PMID: 28606761]
Ramos	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human Ramos cells measured after 3 days Cytotoxicity against human Ramos cells measured after 3 days	[PMID: 28606761]
Rec1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human REC1 cells measured after 3 days Cytotoxicity against human REC1 cells measured after 3 days	[PMID: 28606761]
RERF-LC-MS	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human RERF-LC-MS cells measured after 8 days Cytotoxicity against human RERF-LC-MS cells measured after 8 days	[PMID: 28606761]
RKO	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human RKO cells measured after 8 days Cytotoxicity against human RKO cells measured after 8 days	[PMID: 28606761]
RL	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human RL cells measured after 8 days Cytotoxicity against human RL cells measured after 8 days	[PMID: 28606761]
RL	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human RL cells measured after 3 days Cytotoxicity against human RL cells measured after 3 days	[PMID: 28606761]
RMG-I	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human RMG-I cells measured after 3 days Cytotoxicity against human RMG-I cells measured after 3 days	[PMID: 28606761]
RPMI-8226	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human RPMI-8226 cells measured after 3 days Cytotoxicity against human RPMI-8226 cells measured after 3 days	[PMID: 28606761]
RS4-11	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human RS4-11 cells measured after 8 days Cytotoxicity against human RS4-11 cells measured after 8 days	[PMID: 28606761]
SCC-3	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SCC-3 cells measured after 8 days Cytotoxicity against human SCC-3 cells measured after 8 days	[PMID: 28606761]
SCC-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SCC-3 cells measured after 3 days Cytotoxicity against human SCC-3 cells measured after 3 days	[PMID: 28606761]
SET-2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SET2 cells measured after 3 days Cytotoxicity against human SET2 cells measured after 3 days	[PMID: 28606761]
SK-BR-3	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SK-BR-3 cells measured after 8 days Cytotoxicity against human SK-BR-3 cells measured after 8 days	[PMID: 28606761]
SK-BR-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SK-BR-3 cells measured after 3 days Cytotoxicity against human SK-BR-3 cells measured after 3 days	[PMID: 28606761]
SKM-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SKM-1 cells measured after 8 days Cytotoxicity against human SKM-1 cells measured after 8 days	[PMID: 28606761]
SKM-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SKM-1 cells measured after 3 days Cytotoxicity against human SKM-1 cells measured after 3 days	[PMID: 28606761]
SK-MEL-28	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SK-MEL-28 cells measured after 8 days Cytotoxicity against human SK-MEL-28 cells measured after 8 days	[PMID: 28606761]
SK-MES-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SK-MES-1 cells measured after 8 days Cytotoxicity against human SK-MES-1 cells measured after 8 days	[PMID: 28606761]
SK-MES-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SK-MES-1 cells measured after 3 days Cytotoxicity against human SK-MES-1 cells measured after 3 days	[PMID: 28606761]
SK-OV-3	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SK-OV-3 cells measured after 3 days Cytotoxicity against human SK-OV-3 cells measured after 3 days	[PMID: 28606761]
SNU-182	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-182 cells measured after 3 days Cytotoxicity against human SNU-182 cells measured after 3 days	[PMID: 28606761]
SNU-387	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-387 cells measured after 3 days Cytotoxicity against human SNU-387 cells measured after 3 days	[PMID: 28606761]
SNU-398	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-398 cells measured after 3 days Cytotoxicity against human SNU-398 cells measured after 3 days	[PMID: 28606761]
SNU-423	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-423 cells measured after 3 days Cytotoxicity against human SNU-423 cells measured after 3 days	[PMID: 28606761]
SNU-449	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-449 cells measured after 3 days Cytotoxicity against human SNU-449 cells measured after 3 days	[PMID: 28606761]
SNU-475	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-475 cells measured after 3 days Cytotoxicity against human SNU-475 cells measured after 3 days	[PMID: 28606761]
SNU-C1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SNU-C1 cells measured after 8 days Cytotoxicity against human SNU-C1 cells measured after 8 days	[PMID: 28606761]
SR	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SR cells measured after 8 days Cytotoxicity against human SR cells measured after 8 days	[PMID: 28606761]
SR	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SR cells measured after 3 days Cytotoxicity against human SR cells measured after 3 days	[PMID: 28606761]
SUD4	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-4 cells measured after 8 days Cytotoxicity against human SU-DHL-4 cells measured after 8 days	[PMID: 28606761]
SUD4	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-4 cells measured after 3 days Cytotoxicity against human SU-DHL-4 cells measured after 3 days	[PMID: 28606761]
SU-DHL-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-1 cells measured after 8 days Cytotoxicity against human SU-DHL-1 cells measured after 8 days	[PMID: 28606761]
SU-DHL-1	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-1 cells measured after 3 days Cytotoxicity against human SU-DHL-1 cells measured after 3 days	[PMID: 28606761]
SU-DHL10	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-10 cells measured after 3 days Cytotoxicity against human SU-DHL-10 cells measured after 3 days	[PMID: 28606761]
SU-DHL-16	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-16 cells measured after 8 days Cytotoxicity against human SU-DHL-16 cells measured after 8 days	[PMID: 28606761]
SU-DHL-16	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-16 cells measured after 3 days Cytotoxicity against human SU-DHL-16 cells measured after 3 days	[PMID: 28606761]
SU-DHL-5	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-5 cells measured after 3 days Cytotoxicity against human SU-DHL-5 cells measured after 3 days	[PMID: 28606761]
SU-DHL-6	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-6 cells measured after 3 days Cytotoxicity against human SU-DHL-6 cells measured after 3 days	[PMID: 28606761]
SU-DHL-8	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SU-DHL-8 cells measured after 3 days Cytotoxicity against human SU-DHL-8 cells measured after 3 days	[PMID: 28606761]
SUM149PT	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SUM149PT cells measured after 3 days Cytotoxicity against human SUM149PT cells measured after 3 days	[PMID: 28606761]
SUM-159-PT	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SUM159PT cells measured after 3 days Cytotoxicity against human SUM159PT cells measured after 3 days	[PMID: 28606761]
SUP-B15	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SUP-B15 cells measured after 3 days Cytotoxicity against human SUP-B15 cells measured after 3 days	[PMID: 28606761]
SW1573	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SW1573 cells measured after 8 days Cytotoxicity against human SW1573 cells measured after 8 days	[PMID: 28606761]
SW1573	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SW1573 cells measured after 3 days Cytotoxicity against human SW1573 cells measured after 3 days	[PMID: 28606761]
SW48	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SW48 cells measured after 8 days Cytotoxicity against human SW48 cells measured after 8 days	[PMID: 28606761]
SW480	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SW480 cells measured after 8 days Cytotoxicity against human SW480 cells measured after 8 days	[PMID: 28606761]
SW-620	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SW620 cells measured after 8 days Cytotoxicity against human SW620 cells measured after 8 days	[PMID: 28606761]
SW626	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SW626 cells measured after 3 days Cytotoxicity against human SW626 cells measured after 3 days	[PMID: 28606761]
SW948	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human SW948 cells measured after 8 days Cytotoxicity against human SW948 cells measured after 8 days	[PMID: 28606761]
SW982	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human SW982 cells measured after 3 days Cytotoxicity against human SW982 cells measured after 3 days	[PMID: 28606761]
T47D	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human T47D cells measured after 8 days Cytotoxicity against human T47D cells measured after 8 days	[PMID: 28606761]
T47D	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human T47D cells measured after 3 days Cytotoxicity against human T47D cells measured after 3 days	[PMID: 28606761]
T98G	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human T98G cells measured after 3 days Cytotoxicity against human T98G cells measured after 3 days	[PMID: 28606761]
TERT-RPE1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against hTERT-RPE1 cells measured after 8 days Cytotoxicity against hTERT-RPE1 cells measured after 8 days	[PMID: 28606761]
TK-10	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human TK-10 cells measured after 3 days Cytotoxicity against human TK-10 cells measured after 3 days	[PMID: 28606761]
TMD8	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human TMD8 cells measured after 3 days Cytotoxicity against human TMD8 cells measured after 3 days	[PMID: 28606761]
TOV112D	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human TOV112D cells measured after 3 days Cytotoxicity against human TOV112D cells measured after 3 days	[PMID: 28606761]
TOV21G	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human TOV-21G cells measured after 3 days Cytotoxicity against human TOV-21G cells measured after 3 days	[PMID: 28606761]
TYK-nu	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human TYK-nu cells measured after 3 days Cytotoxicity against human TYK-nu cells measured after 3 days	[PMID: 28606761]
U-266	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human U266B1 cells measured after 3 days Cytotoxicity against human U266B1 cells measured after 3 days	[PMID: 28606761]
U-698-M	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human U-698-M cells measured after 8 days Cytotoxicity against human U-698-M cells measured after 8 days	[PMID: 28606761]
U-698-M	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human U-698-M cells measured after 3 days Cytotoxicity against human U-698-M cells measured after 3 days	[PMID: 28606761]
U-937	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human U-937 cells measured after 8 days Cytotoxicity against human U-937 cells measured after 8 days	[PMID: 28606761]
U-937	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human U-937 cells measured after 3 days Cytotoxicity against human U-937 cells measured after 3 days	[PMID: 28606761]
UACC-62	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human UACC-62 cells measured after 8 days Cytotoxicity against human UACC-62 cells measured after 8 days	[PMID: 28606761]
UMC-11	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human UMC-11 cells measured after 8 days Cytotoxicity against human UMC-11 cells measured after 8 days	[PMID: 28606761]
WiDr	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human WiDr cells measured after 8 days Cytotoxicity against human WiDr cells measured after 8 days	[PMID: 28606761]
WSUDLCL2	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human WSUDLCL2 cells measured after 8 days Cytotoxicity against human WSUDLCL2 cells measured after 8 days	[PMID: 28606761]
WSUDLCL2	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human WSUDLCL2 cells measured after 3 days Cytotoxicity against human WSUDLCL2 cells measured after 3 days	[PMID: 28606761]
YMB-1-E	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human YMB-1-E cells measured after 8 days Cytotoxicity against human YMB-1-E cells measured after 8 days	[PMID: 28606761]
YMB-1-E	IC₅₀	5 μM Compound: 11; GNE-375	Cytotoxicity against human YMB-1-E cells measured after 3 days Cytotoxicity against human YMB-1-E cells measured after 3 days	[PMID: 28606761]
ZR-75-1	IC₅₀	2 μM Compound: 11; GNE-375	Cytotoxicity against human ZR-75-1 cells measured after 8 days Cytotoxicity against human ZR-75-1 cells measured after 8 days	[PMID: 28606761]

Molecular Weight

451.51

Formula

C₂₅H₂₉N₃O₅

CAS No.

1926989-06-1

Appearance

Solid

Color

Off-white to pink

SMILES

O=C1C(NC(C)=C2)=C2C(C3=CC(OC)=C(C(N4CCOCC4)=O)C=C3OC)=CN1C/C=C/C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (110.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2148 mL	11.0740 mL	22.1479 mL
5 mM	0.4430 mL	2.2148 mL	4.4296 mL
10 mM	0.2215 mL	1.1074 mL	2.2148 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (255 KB) HNMR (287 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2148 mL	11.0740 mL	22.1479 mL	55.3698 mL
	5 mM	0.4430 mL	2.2148 mL	4.4296 mL	11.0740 mL
	10 mM	0.2215 mL	1.1074 mL	2.2148 mL	5.5370 mL
	15 mM	0.1477 mL	0.7383 mL	1.4765 mL	3.6913 mL
	20 mM	0.1107 mL	0.5537 mL	1.1074 mL	2.7685 mL
	25 mM	0.0886 mL	0.4430 mL	0.8859 mL	2.2148 mL
	30 mM	0.0738 mL	0.3691 mL	0.7383 mL	1.8457 mL
	40 mM	0.0554 mL	0.2768 mL	0.5537 mL	1.3842 mL
	50 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1074 mL
	60 mM	0.0369 mL	0.1846 mL	0.3691 mL	0.9228 mL
	80 mM	0.0277 mL	0.1384 mL	0.2768 mL	0.6921 mL
	100 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5537 mL

GNE-375 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE-3751926989-06-1GNE375GNE 375Epigenetic Reader DomainBRD9ALDH1A1chromatinInhibitorinhibitorinhibit

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