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GNE-1858 

Cat. No.: HY-135892
Handling Instructions

GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively.

For research use only. We do not sell to patients.

GNE-1858 Chemical Structure

GNE-1858 Chemical Structure

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Description

GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].

In Vitro

Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function[1].

Molecular Weight

428.48

Formula

C₂₁H₂₆F₂N₈

SMILES

FC1(CCN(C2=NC(C3CCNC3)=CC(NC4=CC5=C(C=N4)C=NN5C(C)C)=N2)C1)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GNE-1858GNE1858GNE 1858Othershematopoieticprogenitornegative-feedbackregulatorT-cellreceptorsignalingproliferationInhibitorinhibitorinhibit

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