2680616-96-8
2680616-96-8
Chemical Structure
GNE-1858
- CAS 番号: 2680616-96-8
- Formula:C21H26F2N8
- Molecular Weight:428.48
IUPAC Name: N-(2-(3,3-difluoropyrrolidin-1-yl)-6-(pyrrolidin-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-6-amine
InChIKey: JKPAJCPZQIJPPS-UHFFFAOYSA-N
SMILES: FC1(CCN(C2=NC(C3CCNC3)=CC(NC4=CC5=C(C=N4)C=NN5C(C)C)=N2)C1)F
Biological Activity: GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].
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GNE-1858 | 99.23% | GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively. | ||||||||||||||||||||
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