2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. (S)-GNE-987

(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

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(S)-GNE-987 Chemical Structure

(S)-GNE-987 Chemical Structure

CAS No. : 2738533-33-8

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(S)-GNE-987 Related Antibodies

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Description

(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC)[1].

IC50 & Target[1]

BRD4 (BD1)

4 nM (IC50)

BRD4 (BD2)

3.9 nM (IC50)

VHL

 

Molecular Weight

1096.31

Formula

C56H67F2N9O8S2
CAS No.
SMILES

O=C([C@H](C[C@H](O)C1)N1C([C@@H](NC(CCCCCCCCCCNC(C2=C(CS(=O)(C)=O)C=C(C(N(C3=NC=C(F)C=C3F)C4)=C2)C5=CN(C)C(C6=C5C4=CN6)=O)=O)=O)C(C)(C)C)=O)NCC7=CC=C(C(SC=N8)=C8C)C=C7
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-GNE-987 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-GNE-9872738533-33-8PROTACsEpigenetic Reader DomainchimericBETdegraderEOL-1 cellsHL-60 cellsdegradation-inactiveMYCInhibitorinhibitorinhibit

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