(S)-GNE-987
(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 can be used to design PROTAC-Antibody Conjugate (PAC).
For research use only. We do not sell to patients.
- CAS No.: 2738533-33-8
- Formula: C56H67F2N9O8S2
- Molecular Weight:1096.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
(S)-GNE-987 displays potent anti-MYC activity with an IC50 of 0.48 nM[1].
Chemical Information
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CAS No. 2738533-33-8
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Molecular Weight 1096.31
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Formula C56H67F2N9O8S2
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SMILES
O=C([C@H](C[C@H](O)C1)N1C([C@@H](NC(CCCCCCCCCCNC(C2=C(CS(=O)(C)=O)C=C(C(N(C3=NC=C(F)C=C3F)C4)=C2)C5=CN(C)C(C6=C5C4=CN6)=O)=O)=O)C(C)(C)C)=O)NCC7=CC=C(C(SC=N8)=C8C)C=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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