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GNE-0439 

Cat. No.: HY-123824
Handling Instructions

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders.

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GNE-0439 Chemical Structure

GNE-0439 Chemical Structure

CAS No. : 1241902-40-8

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Description

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].

IC50 & Target

IC50: 0.34 uM (Nav1.7)[1]

Molecular Weight

345.48

Formula

C₂₁H₃₁NO₃

CAS No.

1241902-40-8

SMILES

CC(C)[[email protected]@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GNE-0439
Cat. No.:
HY-123824
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