1241902-40-8
1241902-40-8
Chemical Structure
GNE-0439
- CAS No.: 1241902-40-8
- Formula:C21H31NO3
- Molecular Weight:345.48
IUPAC Name: (4-(4-propylcyclohexyl)benzoyl)-L-valine
InChIKey: SKMKUWKJBZSEJH-RJYAGPCLSA-N
SMILES: CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O
Biological Activity: GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE-0439 | 99.80% | GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-W048283Benzoyl-DL-Valine -
Similarity Score 0.56
HY-160984Rotraxate -
Similarity Score 0.55
HY-783972-((1s,4s)-4-Phenylcyclohexyl)acetic acid -
Similarity Score 0.54
HY-W142019Benzoyl-DL-leucine -
Similarity Score 0.54
HY-W142035N-Benzoyl-L-leucine -
Similarity Score 0.54
HY-162466ABA receptor agonist 1 -
Similarity Score 0.54
HY-106463Hexaprofen -
Similarity Score 0.53
HY-B0422Nateglinide -
Similarity Score 0.52
HY-W011713R(4-Aminobenzoyl)-L-glutamic acid (Standard) -
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