1241902-40-8
1241902-40-8
Chemical Structure
GNE-0439
- CAS No.: 1241902-40-8
- Formula:C21H31NO3
- Molecular Weight:345.48
IUPAC Name: (4-(4-propylcyclohexyl)benzoyl)-L-valine
InChIKey: SKMKUWKJBZSEJH-RJYAGPCLSA-N
SMILES: CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O
Biological Activity: GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
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GNE-0439 | 99.80% | GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders. | ||||||||||||||||||||
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