1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. GNE-9278

GNE-9278 

Cat. No.: HY-129527
Handling Instructions

GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity.

For research use only. We do not sell to patients.

GNE-9278 Chemical Structure

GNE-9278 Chemical Structure

CAS No. : 2315311-83-0

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Description

GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].

IC50 & Target

NMDAR[1]

In Vitro

GNE-9278 (50 μM) slows deactivation with multiple agonists (D-Glu, L-Glu and L-CCG-IV) and enhances the potency of both Glu and Gly[1].
GNE-9278 robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs as measured by calcium influx assays from HEK cell lines with EC50s of 0.74, 3.07, 0.47, and 0.32 μM, respectively[1].

Molecular Weight

429.54

Formula

C₂₁H₂₇N₅O₃S

CAS No.

2315311-83-0

SMILES

O=C1N(N=C2CCC)C(N2)=NC(C)=C1N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GNE-9278GNE9278GNE 9278iGluRIonotropic glutamate receptorspositiveallostericNMDARGluN1transmembranedomainTMDcurrentagonistaffinityInhibitorinhibitorinhibit

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