GNE-140

Cat. No.: HY-118241 Purity: 98.43%: Data Sheet
COA

SDS
Handling Instructions
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GNE-140 (Compound 28) is an external racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B). GNE-140 is an effective lactate dehydrogenase (LDH) inhibitor, with the IC₅₀ values for LDHA and LDHB being 9 nM and 30 nM respectively. GNE-140 can be used in cancer research.

For research use only. We do not sell to patients.

GNE-140 Chemical Structure

CAS No. : 1809794-70-4

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25 mg		Ask For Quote & Lead Time
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100 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of GNE-140:

(S)-GNE-140 In-stock

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Description

IC₅₀ & Target^[4]

LDHA

9 nM (IC₅₀)

LDHB

30 nM (IC₅₀)

Molecular Weight

499.04

Formula

C₂₅H₂₃ClN₂O₃S₂

CAS No.

1809794-70-4

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1NC(C2=CC=C(N3CCOCC3)C=C2)(CC(O)=C1SC4=C(Cl)C=CC=C4)C5=CSC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.43%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (259 KB) HNMR (193 KB) LCMS (160 KB)

Handling Instructions (2659 KB)

References

[1]. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. [Content Brief]

GNE-140 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE-1401809794-70-4GNE140GNE 140Lactate DehydrogenaseLDHxenograft tumorslactate dehydrogenase Cpancreatic cellsMRSAcardiac hypertrophymalate dehydrogenases-1lactate dehydrogenase Blactate dehydrogenase Apulmonary fibrosismalate dehydrogenases-2Inhibitorinhibitorinhibit

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GNE-140

Other Forms of GNE-140:

GNE-140 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

GNE-140 Related Classifications

Molarity Calculator

Dilution Calculator