1. Metabolic Enzyme/Protease
  2. Lactate Dehydrogenase
  3. GNE-140 racemate

GNE-140 racemate 

Cat. No.: HY-100742 Purity: 99.66%
Handling Instructions

GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor.

For research use only. We do not sell to patients.

GNE-140 racemate Chemical Structure

GNE-140 racemate Chemical Structure

CAS No. : 1802977-61-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 370 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GNE-140 racemate:

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Description

GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].

IC50 & Target

Lactate dehydrogenase A (LDHA)[1]

In Vitro

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.04

Formula

C₂₅H₂₃ClN₂O₃S₂

CAS No.

1802977-61-2

SMILES

O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (68.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0038 mL 10.0192 mL 20.0385 mL
5 mM 0.4008 mL 2.0038 mL 4.0077 mL
10 mM 0.2004 mL 1.0019 mL 2.0038 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.66%

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Keywords:

GNE-140GNE140GNE 140Lactate DehydrogenaseLDHracematemixtureglycolysisLDHAanti-cancerInhibitorinhibitorinhibit

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Product Name:
GNE-140 racemate
Cat. No.:
HY-100742
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