GNE-140 racemate
Based on 9 publication(s) in Google Scholar
GNE-140 racemate (Compound 28) is an external racemization mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and it is also an interconformational isomer of GNE-140 (HY-118241). GNE-140 racemate is also an effective lactate dehydrogenase (LDH) inhibitor, with the IC50 values for LDHA and LDHB being 9 nM and 30 nM respectively. GNE-140 racemate can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 1802977-61-2
- Formula: C25H23ClN2O3S2
- Molecular Weight:499.04
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Glycolysis Compound Library
HY-L058
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Glucose Metabolism Compound Library
HY-L092
-
Targeted Diversity Library
HY-L099
-
Heterocyclic Compound Library
HY-L138
-
Metabolic Enzyme Compound Library
HY-L146
-
Cysteine Targeted Covalent Library
HY-L153
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Lactic Acid Metabolic Compound Library
HY-L204
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) GNE-140 racemate
More- Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7. [Abstract]
- Nat Commun. 2023 Jul 14;14(1):4129. [Abstract]
- Int J Biol Macromol. 2025 Sep 10:147598. [Abstract]
- Int J Biol Macromol. 2025 Apr 10;309(Pt 3):142858. [Abstract]
- J Anim Sci Biotechnol. 2025 Dec 18;16(1):174. [Abstract]
- Cell Mol Life Sci. 2019 Apr;76(8):1579-1593. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166550. [Abstract]
- Am J Physiol Heart Circ Physiol. 2021 Jun 1;320(6):H2222-H2239. [Abstract]
- bioRxiv. 2024 June 27.
Biological Activity
|
LDHA |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MIA PaCa-2 | EC50 |
0.25 μM
Compound: 32
|
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
|
[PMID: 25288186] |
Chemical Information
-
CAS No. 1802977-61-2
-
Appearance Solid
-
Molecular Weight 499.04
-
Formula C25H23ClN2O3S2
-
Color White to off-white
-
SMILES
O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
-
Journal Impact Factor
-
Most Recent
-
Gastroenterology
2024 Jan 24:S0016-5085(24)00064-7. PMID: 38272100 -
Nat Commun
2023 Jul 14;14(1):4129. PMID: 37452018 -
Int J Biol Macromol
Targeting and reversing tumor acidic microenvironment with bacterial cellulose-based micelles to enhance immune infiltration. [Abstract]2025 Sep 10:147598. PMID: 40939806 -
Int J Biol Macromol
Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats. [Abstract]2025 Apr 10;309(Pt 3):142858. PMID: 40216110 -
J Anim Sci Biotechnol
Glutamine relieves feed restriction-induced ruminal epithelial function damage through histone lysine lactylation in yaks. [Abstract]2025 Dec 18;16(1):174. PMID: 41408320 -
Cell Mol Life Sci
Impairment of CFTR activity in cultured epithelial cells upregulates the expression and activity of LDH resulting in lactic acid hypersecretion. [Abstract]2019 Apr;76(8):1579-1593. PMID: 30599064 -
Biochim Biophys Acta Mol Basis Dis
Integrated application of transcriptome and metabolomics reveals potential therapeutic targets for the polarization of atherosclerotic macrophages. [Abstract]2022 Dec 1;1868(12):166550. PMID: 36150660 -
Am J Physiol Heart Circ Physiol
Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming. [Abstract]2021 Jun 1;320(6):H2222-H2239. PMID: 33834866 -
Solvent & Solubility
DMSO : 20 mg/mL (40.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0038 mL | 10.0192 mL | 20.0385 mL | 50.0962 mL |
| 5 mM | 0.4008 mL | 2.0038 mL | 4.0077 mL | 10.0192 mL | |
| 10 mM | 0.2004 mL | 1.0019 mL | 2.0038 mL | 5.0096 mL | |
| 15 mM | 0.1336 mL | 0.6679 mL | 1.3359 mL | 3.3397 mL | |
| 20 mM | 0.1002 mL | 0.5010 mL | 1.0019 mL | 2.5048 mL | |
| 25 mM | 0.0802 mL | 0.4008 mL | 0.8015 mL | 2.0038 mL | |
| 30 mM | 0.0668 mL | 0.3340 mL | 0.6679 mL | 1.6699 mL | |
| 40 mM | 0.0501 mL | 0.2505 mL | 0.5010 mL | 1.2524 mL |
GNE-140 racemate Related Classifications
HY-100742 Related Classifications
Powered by Bioz