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LDHA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Lactate Dehydrogenase (13) PDK-1 (2) PROTACs (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (14) Metabolic Disease (2)

18

Inhibitors & Agonists

4

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

LDHA-IN-3 1 Publications Verification	Lactate Dehydrogenase	Cancer
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC₅₀=145.2 nM). LDHA-IN-3 can be used for the research of cancer .

HY-18968

LDHA-IN-4

AZ-33 is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC₅₀ of 0.5 μM and a K_d of 0.093 μM .

LDHA/PDKs-IN-1	PDK-1	Cancer
LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC₅₀s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC₅₀ of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases .

LDHA/PDKs-IN-2	PDK-1	Cancer
LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC₅₀s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC₅₀ of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases .

HY-115875

LDHA-IN-5

Lactate Dehydrogenase Metabolic Disease

LDHA-IN-5 is a novel, potent, dual GO/LDHA inhibitor for primary hyperoxaluria.

LDHA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LDHA Human Pre-designed siRNA Set A contains three designed siRNAs for LDHA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LDHA Human Pre-designed siRNA Set A LDHA Human Pre-designed siRNA Set A

FX-11 10+ Cited Publications LDHA Inhibitor FX11	Lactate Dehydrogenase Apoptosis Reactive Oxygen Species	Cancer
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a K_i of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts .

GNE-140 racemate 5 Publications Verification	Lactate Dehydrogenase	Cancer
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor .

MS6105	PROTACs	Cancer
MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anticancer activity . MS6105 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(R)-GNE-140 5+ Cited Publications	Lactate Dehydrogenase	Cancer
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC₅₀s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

HY-100742B

(S)-GNE-140

Lactate Dehydrogenase Cancer

(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

GSK2837808A Maximum Cited Publications 18 Publications Verification	Lactate Dehydrogenase	Cancer
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC₅₀s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

LDH-IN-1 1 Publications Verification	Lactate Dehydrogenase	Cancer
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC₅₀s of 32 and 27 nM for LDHA and LDHB, respectively.

LDCA	Apoptosis Lactate Dehydrogenase	Cancer
LDCA is a dual-hit metabolic modulator and inhibits *LDH-A* enzyme activity to stimulate apoptosis in the malignant population. LDCA can be used for the research of oncogenic progression .

HY-124309

NHI-2

Lactate Dehydrogenase Cancer

NHI-2 is a potent inhibitor of LDH-A. NHI-2 is an efficient anti-glycolytic agent. NHI-2 has the potential for the research of cancer disease .

HY-W013032A

Oxamic acid sodium 3 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

CHK-336	Lactate Dehydrogenase	Metabolic Disease
CHK-336 (Example 1) is an orally active *LDHA* inhibitor (IC₅₀<1 nM) that inhibits lactate production in mouse hepatocytes. CHK-336 can be used in the study of hyperoxaluria .

Galloflavin 4 Publications Verification	Lactate Dehydrogenase	Cancer
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated K_is for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production .

Species:	Human (1) Mouse (2) Rat (1)
Tag:	His (4)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	LDHA Protein, Rat (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; LDHA; Ldh-1	Rat	E. coli
	The LDHA protein facilitates the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the concomitant exchange of NADH and NAD(+). LDHA Protein, Rat (His) is the recombinant rat-derived LDHA protein, expressed by E. coli , with N-His labeled tag. The total length of LDHA Protein, Rat (His) is 332 a.a., with molecular weight of ~38.7 kDa.

	LDHA Protein, Mouse (HEK293, His) rMuL-lactate dehydrogenase, His; LDHA; Ldh1; L-lactate dehydrogenase	Mouse	HEK293
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+). LDHA Protein, Mouse (HEK293, His) is the recombinant mouse-derived LDHA protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LDHA Protein, Mouse (HEK293, His) is 332 a.a., with molecular weight of ~35.0 kDa.

	LDHA Protein, Human (His) rHuL-lactate dehydrogenase A chain/LDH-A, His; L-Lactate Dehydrogenase A Chain; LDH-A; Cell Proliferation-Inducing Gene 19 Protein; LDH Muscle Subunit; LDH-M; Renal Carcinoma Antigen NY-REN-59; LDHA	Human	E. coli
	LDHA protein catalyzes the stereospecific interconversion of pyruvate and lactate, concomitantly exchanging NADH and NAD(+). LDHA Protein, Human (His) is the recombinant human-derived LDHA protein, expressed by E. coli , with N-6*His labeled tag. The total length of LDHA Protein, Human (His) is 332 a.a., with molecular weight of ~38.0 kDa.

	LDHA Protein, Mouse (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; LDHA; Ldh-1	Mouse	E. coli
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+). LDHA Protein, Mouse (His) is the recombinant mouse-derived LDHA protein, expressed by E. coli , with N-His labeled tag. The total length of LDHA Protein, Mouse (His) is 332 a.a., with molecular weight of ~36.5 kDa.

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