1. Metabolic Enzyme/Protease
  2. Lactate Dehydrogenase
  3. LDHA-IN-3

LDHA-IN-3 

Cat. No.: HY-139319
Handling Instructions

LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer.

For research use only. We do not sell to patients.

LDHA-IN-3 Chemical Structure

LDHA-IN-3 Chemical Structure

CAS No. : 227010-33-5

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Description

LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 145.2 nM (LDHA)[1]

In Vitro

PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1].
PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1].
PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0~500 μM
Incubation Time: 48 hours
Result: Showed cytotoxic effect.
Molecular Weight

301.17

Formula

C₁₃H₉F₃Se

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LDHA-IN-3
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