2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. Galloflavin

Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production.

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Galloflavin Chemical Structure

Galloflavin Chemical Structure

CAS No. : 568-80-9

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

Other Forms of Galloflavin:

Galloflavin Related Antibodies

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Description

Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].

In Vitro

Galloflavin effectively inhibits cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Galloflavin Related Antibodies
Molecular Weight

278.17

Formula

C12H6O8
CAS No.
Appearance

Solid

Color

Brown to breen

SMILES

O=C(OC(C=C1O)=C2OC1=O)C3=C2C(O)=C(O)C(O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (35.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5949 mL 17.9746 mL 35.9492 mL
5 mM 0.7190 mL 3.5949 mL 7.1898 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.36%

COA (253 KB) HNMR (257 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5949 mL 17.9746 mL 35.9492 mL 89.8731 mL
5 mM 0.7190 mL 3.5949 mL 7.1898 mL 17.9746 mL
10 mM 0.3595 mL 1.7975 mL 3.5949 mL 8.9873 mL
15 mM 0.2397 mL 1.1983 mL 2.3966 mL 5.9915 mL
20 mM 0.1797 mL 0.8987 mL 1.7975 mL 4.4937 mL
25 mM 0.1438 mL 0.7190 mL 1.4380 mL 3.5949 mL
30 mM 0.1198 mL 0.5992 mL 1.1983 mL 2.9958 mL
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Galloflavin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galloflavin568-80-9Lactate DehydrogenaseLDHcell growthcancer cell linescell cyclebreast cancermetastasisInhibitorinhibitorinhibit

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