Galloflavin potassium
Based on 15 publication(s) in Google Scholar
Galloflavin potassium is a novel lactate dehydrogenase inhibitor that can be used for the research of cancer. Galloflavin inhibits aerobic glycolysis in PLC/PRF/5 cells and triggers cell death via apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 1780260-20-9
- Formula: C12H5KO8
- Molecular Weight:316.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Galloflavin potassium
More- Cell Res. 2023 Sep;33(9):679-698. [Abstract]
- Drug Resist Updat. 2024 Mar:73:101060. [Abstract]
- Mol Cell. 2024 Feb 15;84(4):744-759.e6. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- J Immunother Cancer. 2025 Dec 3;13(12):e013733. [Abstract]
- Cell Commun Signal. 2025 Feb 19;23(1):99. [Abstract]
- Cell Rep. 2024 Dec 12;43(12):115065. [Abstract]
- Sci Signal. 2026 Mar 3;19(927):eadz6443. [Abstract]
- Commun Biol. 2025 Nov 26;8(1):1761. [Abstract]
- Commun Biol. 2025 Jul 8;8(1):1020. [Abstract]
- Int Immunopharmacol. 2025 Mar 26:150:114265. [Abstract]
- J Immunol. 2025 Nov 6:vkaf218. [Abstract]
- Toxicol Appl Pharmacol. 2025 Aug 10:504:117508. [Abstract]
- SSRN. 2025 Dec 2.
- bioRxiv. 2025 Jul 26:2025.07.22.666143. [Abstract]
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
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Apoptosis Analysis
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Cell Imaging/Staining
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IP
Biological Activity
Chemical Information
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CAS No. 1780260-20-9
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Molecular Weight 316.26
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Formula C12H5KO8
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SMILES
O=C1OC2=C(C=C1O[K])OC(C3=C2C(O)=C(O)C(O)=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Cell Res
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure. [Abstract]2023 Sep;33(9):679-698. PMID: 37443257
Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698. [Abstract]
H9c2 cells stimulated with or without Galloflavin (LDHA inhibitor; 10 μM; 24 h) were lysed and immunoprecipitated using anti-α-MHC antibody or control IgG, followed by detection of αMHC K1897 Lactyl Lysine.
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Drug Resist Updat
Polyphenol nanocomplex modulates lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect. [Abstract]2024 Mar:73:101060. PMID: 38309140
Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060. [Abstract]
Inhibition of extracellular lactate secretion after different treatments (top). The concentration of pyruvate after various treatments (bottom). PBS, Galloflavin (GF;8 μM), and PCGF (containing GF 8 μM) were used to coculture with 4T1 cells. After incubation for 48 h, the tumor cell supernatant was collected for lactate and pyruvate measurement.
Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060. [Abstract]
Cell viability after various treatments. The MTT assay was conducted after various treatments (PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 48 h in 4T1 cells.
Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060. [Abstract]
Characteristic flow cytometry profiles depicting 4T1 cell apoptosis post different treatment interventions. PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 24 h.
Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060. [Abstract]
Results of the live/dead co-staining assay after different treatments (top). Levels of DNA double-strand breaks in 4T1 cells following treatments with PBS, CA, Galloflavin (GF), PCGF, and PCGF+Laser (bottom). PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 24 h.
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Mol Cell
Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation. [Abstract]2024 Feb 15;84(4):744-759.e6. PMID: 38266638 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
J Immunother Cancer
2025 Dec 3;13(12):e013733. PMID: 41339107 -
Cell Commun Signal
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects. [Abstract]2025 Feb 19;23(1):99. PMID: 39972350 -
Cell Rep
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy. [Abstract]2024 Dec 12;43(12):115065. PMID: 39671292 -
Sci Signal
Glucose metabolism sustains aberrant STAT3 signaling in colorectal cancer through glycosylated local signaling factors. [Abstract]2026 Mar 3;19(927):eadz6443. PMID: 41774818 -
Commun Biol
Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C. [Abstract]2025 Nov 26;8(1):1761. PMID: 41298813 -
Commun Biol
CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment. [Abstract]2025 Jul 8;8(1):1020. PMID: 40629043 -
Int Immunopharmacol
Galloflavin mitigates acute kidney injury by suppressing LDHA-dependent macrophage glycolysis. [Abstract]2025 Mar 26:150:114265. PMID: 39955920 -
J Immunol
The involvement of CLec-HTM/IgR-Syk-BCL10-mTOR/ERK signaling pathway in immune priming of oysters. [Abstract]2025 Nov 6:vkaf218. PMID: 41206721 -
Toxicol Appl Pharmacol
Myocardial ischemia/reperfusion-induced glycolysis enhances damage through TRPM7 histone lactylation. [Abstract]2025 Aug 10:504:117508. PMID: 40796076 -
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bioRxiv
Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors. [Abstract]2025 Jul 26:2025.07.22.666143. PMID: 40777356
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)