2. Metabolic Enzyme/Protease Apoptosis
  3. Lactate Dehydrogenase Apoptosis
  4. Galloflavin potassium

Galloflavin potassium is a novel lactate dehydrogenase inhibitor that can be used for the research of cancer. Galloflavin inhibits aerobic glycolysis in PLC/PRF/5 cells and triggers cell death via apoptosis.

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CAS No. : 1780260-20-9

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Galloflavin potassium Related Antibodies

Top Publications Citing Use of Products

    Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060.

    Inhibition of extracellular lactate secretion after different treatments (top). The concentration of pyruvate after various treatments (bottom). PBS, Galloflavin (GF;8 μM), and PCGF (containing GF 8 μM) were used to coculture with 4T1 cells. After incubation for 48 h, the tumor cell supernatant was collected for lactate and pyruvate measurement.

    Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060.

    Cell viability after various treatments. The MTT assay was conducted after various treatments (PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 48 h in 4T1 cells.

    Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060.

    Characteristic flow cytometry profiles depicting 4T1 cell apoptosis post different treatment interventions. PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 24 h.

    Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Mar:73:101060.

    Results of the live/dead co-staining assay after different treatments (top). Levels of DNA double-strand breaks in 4T1 cells following treatments with PBS, CA, Galloflavin (GF), PCGF, and PCGF+Laser (bottom). PBS, CA 10 µM, Galloflavin (GF) 8 µM, PCGF (equivalent to CA 10 µM, GF 8 µM), and PCGF+Laser) for 24 h.

    Galloflavin potassium purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698.  [Abstract]

    H9c2 cells stimulated with or without Galloflavin (LDHA inhibitor; 10 μM; 24 h) were lysed and immunoprecipitated using anti-α-MHC antibody or control IgG, followed by detection of αMHC K1897 Lactyl Lysine.

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    Description

    Galloflavin potassium is a novel lactate dehydrogenase inhibitor that can be used for the research of cancer. Galloflavin inhibits aerobic glycolysis in PLC/PRF/5 cells and triggers cell death via apoptosis[1].

    Molecular Weight

    316.26

    Formula

    C12H5KO8
    CAS No.
    SMILES

    O=C1OC2=C(C=C1O[K])OC(C3=C2C(O)=C(O)C(O)=C3)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Galloflavin potassium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Galloflavin1780260-20-9Lactate DehydrogenaseApoptosisLDHLactate Dehydrogenase InhibitorCancerPLC/PRF/5 cellsapoptosisInhibitorinhibitorinhibit

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