1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. GNE-8324

GNE-8324 

Cat. No.: HY-107498
Handling Instructions

GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.

For research use only. We do not sell to patients.

GNE-8324 Chemical Structure

GNE-8324 Chemical Structure

CAS No. : 1698901-76-6

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Description

GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons[1].

In Vitro

A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.42

Formula

C18H18FN3OS

CAS No.
SMILES

O=C1C=C(CN(C2=CC=C(F)C=C2)CC)N=C3N1C(CCC4)=C4S3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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GNE-8324
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