1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

GNE 5729 

Cat. No.: HY-107409
Handling Instructions

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.

For research use only. We do not sell to patients.

GNE 5729 Chemical Structure

GNE 5729 Chemical Structure

CAS No. : 2026635-66-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.

IC50 & Target

EC50: 37 nM (GluN2A), 4.7 μM (GluN2C), 9.5 μM (GluN2D)[1]

In Vitro

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1].

References
Molecular Weight

428.20

Formula

C₁₇H₁₀Cl₂F₃N₅O

CAS No.

2026635-66-3

SMILES

ClC1=C([[email protected]]2[[email protected]](C#N)C2)N3C(C=C1)=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC3=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GNE 5729
Cat. No.:
HY-107409
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GNE 5729

Cat. No.: HY-107409