N-Acetylmannosamine 6-phosphate sodium salt
Based on 1 Customer Validation
N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 335275-62-2
- Formula: C8H15NNaO9P
- Molecular Weight:323.17
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
N-Acetylmannosamine 6-phosphate (ManNAc-6P) (increasing concentrations; standard EMSA conditions) inhibits the binding of S. aureus NanR-MBP protein to the nanA promoter region in an EMSA-based assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 335275-62-2
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Appearance Solid
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Molecular Weight 323.17
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Formula C8H15NNaO9P
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Color White to off-white
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SMILES
O=P(O)(O[Na])OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
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Synonyms
ManNAc-6P sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (309.43 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Olson ME, et al. Sialic acid catabolism in Staphylococcus aureus. J Bacteriol. 2013;195(8):1779-1788. [Content Brief]
[2]. Pertusati F, et al. Synthesis of 2-Acetamido-1,3,4-Tri-O-Acetyl-2-Deoxy-D-Mannopyranose -6-Phosphate Prodrugs as Potential Therapeutic Agents. Curr Protoc. 2022;2(8):e500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.0943 mL | 15.4717 mL | 30.9435 mL | 77.3587 mL |
| 5 mM | 0.6189 mL | 3.0943 mL | 6.1887 mL | 15.4717 mL | |
| 10 mM | 0.3094 mL | 1.5472 mL | 3.0943 mL | 7.7359 mL | |
| 15 mM | 0.2063 mL | 1.0314 mL | 2.0629 mL | 5.1572 mL | |
| 20 mM | 0.1547 mL | 0.7736 mL | 1.5472 mL | 3.8679 mL | |
| 25 mM | 0.1238 mL | 0.6189 mL | 1.2377 mL | 3.0943 mL | |
| 30 mM | 0.1031 mL | 0.5157 mL | 1.0314 mL | 2.5786 mL | |
| 40 mM | 0.0774 mL | 0.3868 mL | 0.7736 mL | 1.9340 mL | |
| 50 mM | 0.0619 mL | 0.3094 mL | 0.6189 mL | 1.5472 mL | |
| 60 mM | 0.0516 mL | 0.2579 mL | 0.5157 mL | 1.2893 mL | |
| 80 mM | 0.0387 mL | 0.1934 mL | 0.3868 mL | 0.9670 mL | |
| 100 mM | 0.0309 mL | 0.1547 mL | 0.3094 mL | 0.7736 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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