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Cat. No.: HY-182740

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GSH linker-2

GSH linker-2 is an ADC linker that can be used to synthesize GNE-987 GSH linker-2 (HY-138634).

For research use only. We do not sell to patients.

Formula: C₅H₁₀O₅S₂
Molecular Weight:214.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSH linker-2 Chemical Structure

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

GSH linker-2 is an ADC linker that can be used to synthesize GNE-987 GSH linker-2 (HY-138634)^[1].

All ADC Linkers Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 214.26
Formula C₅H₁₀O₅S₂
SMILES

OC(OC[C@@H](C)SS(C)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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GSH linker-2

All ADC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GSH linker-2 Related Classifications

HY-182740 Related Classifications