1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

GNE-371 

Cat. No.: HY-112803
Handling Instructions

GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).

For research use only. We do not sell to patients.

GNE-371 Chemical Structure

GNE-371 Chemical Structure

CAS No. : 1926986-36-8

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).

IC50 & Target

IC50: 10 nM (TAF1(2))[1].

In Vitro

GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3176 mL 11.5878 mL 23.1755 mL
5 mM 0.4635 mL 2.3176 mL 4.6351 mL
10 mM 0.2318 mL 1.1588 mL 2.3176 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.49

Formula

C₂₄H₂₅N₅O₃

CAS No.

1926986-36-8

SMILES

O=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GNE-371
Cat. No.:
HY-112803
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GNE-371

Cat. No.: HY-112803