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  2. Estrogen Receptor/ERR
  3. GNE-502

GNE-502 

Cat. No.: HY-132294
Handling Instructions

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

GNE-502 Chemical Structure

GNE-502 Chemical Structure

CAS No. : 1953134-16-1

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Description

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].

IC50 & Target

ER[1]

In Vivo

GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1].
.. GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 and 100 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.
Molecular Weight

471.59

Formula

C₂₅H₃₀FN₃O₃S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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GNE-502
Cat. No.:
HY-132294
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