1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. GNE-6776

GNE-6776 

Cat. No.: HY-107986 Purity: 98.29%
Handling Instructions

GNE-6776 is a selective and orally bioavailable USP7 inhibitor.

For research use only. We do not sell to patients.

GNE-6776 Chemical Structure

GNE-6776 Chemical Structure

CAS No. : 2009273-71-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1].

IC50 & Target

USP7[1]

In Vitro

GNE-6776 significantly inhibits USP7 at 15 µM. GNE-6776 is a highly selective USP7 inhibitor against both recombinant and endogenous cellular deubiquitinases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft[1]
Dosage: 100 or 200 mg/kg
Administration: Oral gavage on a once or twice daily schedule; for 10 days
Result: Significant EOL-1 xenograft growth inhibition.
Molecular Weight

348.40

Formula

C₂₀H₂₀N₄O₂

CAS No.

2009273-71-4

SMILES

CCC(C(C1=CC=C(O)C=C1)=C(N)N=C2)=C2C3=CC=C(C(NC)=O)N=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (287.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8703 mL 14.3513 mL 28.7026 mL
5 mM 0.5741 mL 2.8703 mL 5.7405 mL
10 mM 0.2870 mL 1.4351 mL 2.8703 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

GNE-6776GNE6776GNE 6776DeubiquitinaseDUBsInhibitorinhibitorinhibit

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GNE-6776
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HY-107986
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