1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

GNE 0723 

Cat. No.: HY-108337
Handling Instructions

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

For research use only. We do not sell to patients.

GNE 0723 Chemical Structure

GNE 0723 Chemical Structure

CAS No. : 1883518-31-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

IC50 & Target

EC50: 21 nM (GluN2A), 7.4 μM (GluN2C), 6.2 μM (GluN2D)[1]

In Vitro

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1378 mL 10.6888 mL 21.3776 mL
5 mM 0.4276 mL 2.1378 mL 4.2755 mL
10 mM 0.2138 mL 1.0689 mL 2.1378 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

467.78

Formula

C₁₆H₈ClF₆N₅OS

CAS No.

1883518-31-7

SMILES

N#C[[email protected]]1[[email protected]](C2=C(C(F)(F)F)SC3=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC(N32)=O)C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GNE 0723
Cat. No.:
HY-108337
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GNE 0723

Cat. No.: HY-108337