GNE-3565
GNE-3565 is an arylsulfonamide class NaV1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain.
For research use only. We do not sell to patients.
- CAS No.: 2222537-72-4
- Formula: C25H26ClF4N5O2S
- Molecular Weight:572.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GNE-3565 (50 μM; 10 min at 22 °C) binds to the VSD4 domain of the VSD4-NaV1.7-NaVPas chimeric channel in a pose similar to the arylsulfonamide inhibitor GX-936, forming key interactions with the R4 gating charge and subtype-selectivity residues Tyr1537 and Trp1538[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222537-72-4
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Molecular Weight 572.02
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Formula C25H26ClF4N5O2S
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SMILES
CN(C)[C@@H](C[C@@H](C1=CC(C(F)(F)F)=CC=C1)CC2)[C@H]2NC3=C(C=C(C(F)=C3)S(NC4=NC=NC=C4)(=O)=O)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GNE-3565 Related Classifications
HY-185334 Related Classifications
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