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LIN7A - lin-7 homolog A, crumbs cell polarity complex component Gene

Also Known as LIN7; MALS1; VELI1; LIN-7A; MALS-1; TIP-33

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8825

About LIN7A

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:80,792,520-80,937,934 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 7.9), brain (RPKM 5.7) and 20 other tissues.

Summary

The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]

LIN7A Products (2)

mRNA	Protein	Name
NM_001324423.2	NP_001311352.1	protein lin-7 homolog A isoform 2
NM_004664.4	NP_004655.1	protein lin-7 homolog A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables L27 domain binding	IPI IPI: Inferred from physical interaction	17237226	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11311936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN7A Protein Structure

L27

PDZ

0
100
200
233 a.a.

Protein Preferred Names	Protein Names
protein lin-7 homolog A	mammalian lin-seven protein 1

LIN7A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LIN7A	O14910	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-2	Y2H Array	31515488
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-2	Validated Y2H	25416956
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-2	Y2H Array	25416956
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936-4	Y2H Array	32296183
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936-4	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936-4	Validated Y2H	32296183
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936	Y2H Array	25416956
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936	Anti Tag CoIP	24366813
Intra	LIN7A	O14910	CASK	Homo sapiens	O14936	Y2H Prey Pooling	25416956
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-4	Validated Y2H	32296183
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-4	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	MPP2	Homo sapiens	Q14168-4	Y2H Array	32296183
Intra	LIN7A	O14910	PALS1	Homo sapiens	Q8N3R9	Anti Tag CoIP	24366813
Intra	LIN7A	O14910	PALS1	Homo sapiens	Q8N3R9	Y2H Array	31515488
Intra	LIN7A	O14910	PALS1	Homo sapiens	Q8N3R9	Y2H Prey Pooling	25416956
Intra	LIN7A	O14910	PALS1	Homo sapiens	Q8N3R9	Validated Y2H	32296183
Intra	LIN7A	O14910	MPP7	Homo sapiens	Q5T2T1	Y2H Array	32296183
Intra	LIN7A	O14910	MPP7	Homo sapiens	Q5T2T1	Anti Tag CoIP	24366813
Intra	LIN7A	O14910	MPP7	Homo sapiens	Q5T2T1	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	MPP7	Homo sapiens	Q5T2T1	Validated Y2H	32296183
Intra	LIN7A	O14910	PALS2	Homo sapiens	Q9NZW5	Y2H Array	32296183
Intra	LIN7A	O14910	PALS2	Homo sapiens	Q9NZW5	Validated Y2H	32296183
Intra	LIN7A	O14910	PALS2	Homo sapiens	Q9NZW5	Anti Tag CoIP	24366813
Intra	LIN7A	O14910	PALS2	Homo sapiens	Q9NZW5	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	ZYX	Homo sapiens	Q15942	Y2H Array	25416956
Intra	LIN7A	O14910	ZYX	Homo sapiens	Q15942	Y2H Prey Pooling	25416956
Intra	LIN7A	O14910	ZYX	Homo sapiens	Q15942	Validated Y2H	25416956
Intra	LIN7A	O14910	MPP3	Homo sapiens	Q13368	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	MPP3	Homo sapiens	Q13368	Y2H Array	32296183
Intra	LIN7A	O14910	MPP3	Homo sapiens	Q13368	Validated Y2H	32296183
Intra	LIN7A	O14910	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	LIN7A	O14910	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	LIN7A	O14910	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	LIN7A	O14910	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	LIN7A	O14910	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	LIN7A	O14910	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	32296183
Intra	LIN7A	O14910	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183
Intra	LIN7A	O14910	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	LIN7A	O14910	ECM1	Homo sapiens	Q16610	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Tubotympanic Suppurative Otitis Media	Chronic Tubotympanic Disease Benign Chronic Suppurative Otitis Media
Chronic Atticoantral Disease	Chronic Atticoantral Suppurative Otitis Media Persistent Mucosal Disease Chronic Atticoantral Disorder
Syndromic X-Linked Intellectual Disability Najm Type	Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia Micpch X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Adhesive Otitis Media	Adhesive Middle Ear Disease Chronic Adhesive Otitis Media Adhesive Otitis Fibrotic Adhesive Otitis Media Adhesive Disorder Of Middle Ear
Retinitis Pigmentosa 12	RP12 Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium Rp With Or Without Pprpe Retinitis Pigmentosa-12
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Opitz-Kaveggia Syndrome	Fg Syndrome Fgs1 Fgs Keller Syndrome OKS Fg Syndrome 1 Fg Syndrome Type 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07676	LIN7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LIN7A	VGNC	VGNC:74068
Mus musculus	LIN7A	MGD	MGI:2135609
Bos taurus	LIN7A	VGNC	VGNC:30895
Felis catus	LIN7A	VGNC	VGNC:63233
Rattus norvegicus	LIN7A	RGD	RGD:621256
Canis familiaris	LIN7A	VGNC	VGNC:42686
Others	LIN7A	NCBI